Endocrine Health in Childhood Cancer Survivors

Hanneke M van Santen; Wassim Chemaitilly; Lillian R Meacham; Emily S Tonorezos; Sogol Mostoufi-Moab

doi:10.1016/j.pcl.2020.08.002

Endocrine Health in Childhood Cancer Survivors

Hanneke M van Santen, Wassim Chemaitilly, Lillian R Meacham, Emily S Tonorezos, Sogol Mostoufi-Moab

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Endocrine late effects, including reproductive disorders and secondary thyroid cancer, have been reported in up to 50 %childhood cancer survivors (CCS) more than 5 years after treatment. Most endocrine disorders are amenable to treatment; awareness of symptoms is therefore of great importance. Recognition of these symptoms may be delayed however because many are nonspecific. Timely treatment of endocrine disorders improves quality of life in CCS and prevents possible consequences, such as short stature, bone and cardiovascular disorders, and depression. At-risk CCS must therefore be regularly and systematically monitored. This article provides a summary of the most commonly reported endocrine late effects in CCS.

Original language	English
Pages (from-to)	1171-1186
Number of pages	16
Journal	The pediatric clinics of North America
Volume	67
Issue number	6
DOIs	https://doi.org/10.1016/j.pcl.2020.08.002
Publication status	Published - Dec 2020

Keywords

Bone health
Childhood cancer survivor
Growth hormone deficiency
Hypothyroidism
Late effects
Metabolic syndrome
Radiation effects
Secondary thyroid cancer

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10.1016/j.pcl.2020.08.002

1-s2.0-S0031395520301103-mainFinal published version, 438 KBLicence: CC BY

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title = "Endocrine Health in Childhood Cancer Survivors",

abstract = "Endocrine late effects, including reproductive disorders and secondary thyroid cancer, have been reported in up to 50 %childhood cancer survivors (CCS) more than 5 years after treatment. Most endocrine disorders are amenable to treatment; awareness of symptoms is therefore of great importance. Recognition of these symptoms may be delayed however because many are nonspecific. Timely treatment of endocrine disorders improves quality of life in CCS and prevents possible consequences, such as short stature, bone and cardiovascular disorders, and depression. At-risk CCS must therefore be regularly and systematically monitored. This article provides a summary of the most commonly reported endocrine late effects in CCS.",

keywords = "Bone health, Childhood cancer survivor, Growth hormone deficiency, Hypothyroidism, Late effects, Metabolic syndrome, Radiation effects, Secondary thyroid cancer",

author = "{van Santen}, {Hanneke M} and Wassim Chemaitilly and Meacham, {Lillian R} and Tonorezos, {Emily S} and Sogol Mostoufi-Moab",

note = "Funding Information: H.M. van Santen has received speakers fees from Pfizer BV and Ferring BV. The remaining authors have nothing to disclose. Publisher Copyright: {\textcopyright} 2020 The Author(s) Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.pcl.2020.08.002",

language = "English",

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AU - Tonorezos, Emily S

AU - Mostoufi-Moab, Sogol

N1 - Funding Information: H.M. van Santen has received speakers fees from Pfizer BV and Ferring BV. The remaining authors have nothing to disclose. Publisher Copyright: © 2020 The Author(s) Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/12

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N2 - Endocrine late effects, including reproductive disorders and secondary thyroid cancer, have been reported in up to 50 %childhood cancer survivors (CCS) more than 5 years after treatment. Most endocrine disorders are amenable to treatment; awareness of symptoms is therefore of great importance. Recognition of these symptoms may be delayed however because many are nonspecific. Timely treatment of endocrine disorders improves quality of life in CCS and prevents possible consequences, such as short stature, bone and cardiovascular disorders, and depression. At-risk CCS must therefore be regularly and systematically monitored. This article provides a summary of the most commonly reported endocrine late effects in CCS.

AB - Endocrine late effects, including reproductive disorders and secondary thyroid cancer, have been reported in up to 50 %childhood cancer survivors (CCS) more than 5 years after treatment. Most endocrine disorders are amenable to treatment; awareness of symptoms is therefore of great importance. Recognition of these symptoms may be delayed however because many are nonspecific. Timely treatment of endocrine disorders improves quality of life in CCS and prevents possible consequences, such as short stature, bone and cardiovascular disorders, and depression. At-risk CCS must therefore be regularly and systematically monitored. This article provides a summary of the most commonly reported endocrine late effects in CCS.

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Endocrine Health in Childhood Cancer Survivors

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Keywords

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