TY - JOUR
T1 - EndoCompass project
T2 - research roadmap for endocrine causes and consequences of cancer
AU - Carroll, Jason S.
AU - Castinetti, Frederic
AU - Follin, Cecilia
AU - Luque, Raul M.
AU - Verrijn Stuart, Annemarie A.
AU - Giwercman, Aleksander
AU - Grozinsky-Glasberg, Simona
AU - Krausz, Csilla
AU - Paschou, Stavroula A.
AU - Peeters, Robin
AU - Pieterman, Carolina R.C.
AU - Romanet, Pauline
AU - Jiménez-Vacas, Juan M.
AU - van Santen, Hanneke M.
AU - Zibar Tomšic, Karin
N1 - Publisher Copyright:
© The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.
PY - 2025/10/1
Y1 - 2025/10/1
N2 - BACKGROUND: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology-aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.RESULTS: Research priorities encompass re-evaluation of progestins in breast cancer treatment; strategies to disrupt AR signalling in prostate cancer; surveillance for endocrine sequelae in childhood cancer survivors; understanding genotoxic effects on fertility; and management of checkpoint inhibitor endocrinopathies and familial cancer syndromes. Emphasis is placed on precision medicine and metabolic factors in cancer.CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into cancer-endocrine pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.
AB - BACKGROUND: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology-aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.RESULTS: Research priorities encompass re-evaluation of progestins in breast cancer treatment; strategies to disrupt AR signalling in prostate cancer; surveillance for endocrine sequelae in childhood cancer survivors; understanding genotoxic effects on fertility; and management of checkpoint inhibitor endocrinopathies and familial cancer syndromes. Emphasis is placed on precision medicine and metabolic factors in cancer.CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into cancer-endocrine pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.
KW - EndoCompass
KW - cancer syndrome
KW - endocrine-related cancer
KW - funding
KW - roadmap
UR - https://www.scopus.com/pages/publications/105019114419
U2 - 10.1093/ejendo/lvaf066
DO - 10.1093/ejendo/lvaf066
M3 - Review article
C2 - 41104473
SN - 0804-4643
VL - 193
SP - ii35-ii46
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - Supplement_2
ER -