TY - JOUR
T1 - Emerging roles of cohesin-STAG2 in cancer
AU - Scott, Julia S.
AU - Al Ayadi, Loubna
AU - Epeslidou, Emmanouela
AU - van Scheppingen, Roan H.
AU - Mukha, Anna
AU - Kaaij, Lucas J.T.
AU - Lutz, Catrin
AU - Prekovic, Stefan
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature Limited 2024.
PY - 2025
Y1 - 2025
N2 - Cohesin, a crucial regulator of genome organisation, plays a fundamental role in maintaining chromatin architecture as well as gene expression. Among its subunits, STAG2 stands out because of its frequent deleterious mutations in various cancer types, such as bladder cancer and melanoma. Loss of STAG2 function leads to significant alterations in chromatin structure, disrupts transcriptional regulation, and impairs DNA repair pathways. In this review, we explore the molecular mechanisms underlying cohesin-STAG2 function, highlighting its roles in healthy cells and its contributions to cancer biology, showing how STAG2 dysfunction promotes tumourigenesis and presents opportunities for targeted therapeutic interventions.
AB - Cohesin, a crucial regulator of genome organisation, plays a fundamental role in maintaining chromatin architecture as well as gene expression. Among its subunits, STAG2 stands out because of its frequent deleterious mutations in various cancer types, such as bladder cancer and melanoma. Loss of STAG2 function leads to significant alterations in chromatin structure, disrupts transcriptional regulation, and impairs DNA repair pathways. In this review, we explore the molecular mechanisms underlying cohesin-STAG2 function, highlighting its roles in healthy cells and its contributions to cancer biology, showing how STAG2 dysfunction promotes tumourigenesis and presents opportunities for targeted therapeutic interventions.
UR - http://www.scopus.com/inward/record.url?scp=85210600714&partnerID=8YFLogxK
U2 - 10.1038/s41388-024-03221-y
DO - 10.1038/s41388-024-03221-y
M3 - Review article
AN - SCOPUS:85210600714
SN - 0950-9232
VL - 44
SP - 277
EP - 287
JO - Oncogene
JF - Oncogene
IS - 5
M1 - 70
ER -