TY - JOUR
T1 - Emerging roles for chemokines and cytokines as orchestrators of immunopathology in Sjögren's syndrome
AU - Blokland, Sofie L.M.
AU - Flessa, Christina Maria
AU - Van Roon, Joel A.G.
AU - Mavragani, Clio P.
N1 - Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: [email protected].
PY - 2021/7/1
Y1 - 2021/7/1
N2 - In primary SS (pSS), chemokines and cytokines orchestrate immunopathology driven by a complex network of interacting inflammatory cells. In recent years, the importance of chemotactic and non-chemotactic cytokines that control function, movement and placing of all cells within the inflamed exocrine glands and directing immunopathology has become increasingly clear. This paper reviews the current knowledge on chemokines and focuses on the emerging roles of novel chemotactic and non-chemotactic mediators in pSS. It highlights their contribution to pathogenic processes such as B cell hyperactivity and the formation of ectopic lymphoid structures. To this end, the role of acquired (CXCR5/CCR9 Th-cell-mediated) and innate (inflammasome/IL-1/IL-18-mediated) pathways in steering immunopathology is discussed.
AB - In primary SS (pSS), chemokines and cytokines orchestrate immunopathology driven by a complex network of interacting inflammatory cells. In recent years, the importance of chemotactic and non-chemotactic cytokines that control function, movement and placing of all cells within the inflamed exocrine glands and directing immunopathology has become increasingly clear. This paper reviews the current knowledge on chemokines and focuses on the emerging roles of novel chemotactic and non-chemotactic mediators in pSS. It highlights their contribution to pathogenic processes such as B cell hyperactivity and the formation of ectopic lymphoid structures. To this end, the role of acquired (CXCR5/CCR9 Th-cell-mediated) and innate (inflammasome/IL-1/IL-18-mediated) pathways in steering immunopathology is discussed.
KW - chemokines
KW - IL-1 cytokine family
KW - inflammasome
KW - Sjögren's syndrome
UR - http://www.scopus.com/inward/record.url?scp=85110494647&partnerID=8YFLogxK
U2 - 10.1093/rheumatology/key438
DO - 10.1093/rheumatology/key438
M3 - Review article
C2 - 30838419
AN - SCOPUS:85110494647
SN - 1462-0324
VL - 60
SP - 3072
EP - 3087
JO - Rheumatology (United Kingdom)
JF - Rheumatology (United Kingdom)
IS - 7
ER -