Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans

Inge Van Loo; Xander Huijsdens; Edine Tiemersma; Albert De Neeling; Nienke Van De Sande-Bruinsma; Desiree Beaujean; Andreas Voss; Jan Kluytmans

doi:10.3201/eid1312.070384

Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans

Inge Van Loo
, Xander Huijsdens
, Edine Tiemersma
, Albert De Neeling
, Nienke Van De Sande-Bruinsma
, Desiree Beaujean
, Andreas Voss
, Jan Kluytmans^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

352 Citations (Scopus)

Abstract

In 2003 in the Netherlands, a new methicillin-resistant Staphylococcus aureus (MRSA) strain emerged that could not be typed with Sma1 pulsed-field gel electrophoresis (NT-MRSA). The association of NT-MRSA in humans with a reservoir in animals was investigated. The frequency of NT-MRSA increased from 0% in 2002 to >21% after intensi-fied surveillance was implemented in July 2006. Geographically, NT-MRSA clustered with pig farming. A case-control study showed that carriers of NT-MRSA were more often pig or cattle farmers (pig farmers odds ratio [OR] 12.2, 95% confidence interval [CI] 3.1-48.6; cattle farmers OR 19.7, 95% CI 2.3-169.5). Molecular typing showed that the NTMRSA strains belonged to a new clonal complex, ST 398. This study shows that MRSA from an animal reservoir has recently entered the human population and is now responsible for >20% of all MRSA in the Netherlands.

Original language	English
Pages (from-to)	1834-1839
Number of pages	6
Journal	Emerging infectious diseases
Volume	13
Issue number	12
DOIs	https://doi.org/10.3201/eid1312.070384
Publication status	Published - Dec 2007
Externally published	Yes

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title = "Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans",

abstract = "In 2003 in the Netherlands, a new methicillin-resistant Staphylococcus aureus (MRSA) strain emerged that could not be typed with Sma1 pulsed-field gel electrophoresis (NT-MRSA). The association of NT-MRSA in humans with a reservoir in animals was investigated. The frequency of NT-MRSA increased from 0\% in 2002 to >21\% after intensi-fied surveillance was implemented in July 2006. Geographically, NT-MRSA clustered with pig farming. A case-control study showed that carriers of NT-MRSA were more often pig or cattle farmers (pig farmers odds ratio [OR] 12.2, 95\% confidence interval [CI] 3.1-48.6; cattle farmers OR 19.7, 95\% CI 2.3-169.5). Molecular typing showed that the NTMRSA strains belonged to a new clonal complex, ST 398. This study shows that MRSA from an animal reservoir has recently entered the human population and is now responsible for >20\% of all MRSA in the Netherlands.",

author = "\{Van Loo\}, Inge and Xander Huijsdens and Edine Tiemersma and \{De Neeling\}, Albert and \{Van De Sande-Bruinsma\}, Nienke and Desiree Beaujean and Andreas Voss and Jan Kluytmans",

year = "2007",

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AU - Van Loo, Inge

AU - Huijsdens, Xander

AU - Tiemersma, Edine

AU - De Neeling, Albert

AU - Van De Sande-Bruinsma, Nienke

AU - Beaujean, Desiree

AU - Voss, Andreas

AU - Kluytmans, Jan

PY - 2007/12

Y1 - 2007/12

N2 - In 2003 in the Netherlands, a new methicillin-resistant Staphylococcus aureus (MRSA) strain emerged that could not be typed with Sma1 pulsed-field gel electrophoresis (NT-MRSA). The association of NT-MRSA in humans with a reservoir in animals was investigated. The frequency of NT-MRSA increased from 0% in 2002 to >21% after intensi-fied surveillance was implemented in July 2006. Geographically, NT-MRSA clustered with pig farming. A case-control study showed that carriers of NT-MRSA were more often pig or cattle farmers (pig farmers odds ratio [OR] 12.2, 95% confidence interval [CI] 3.1-48.6; cattle farmers OR 19.7, 95% CI 2.3-169.5). Molecular typing showed that the NTMRSA strains belonged to a new clonal complex, ST 398. This study shows that MRSA from an animal reservoir has recently entered the human population and is now responsible for >20% of all MRSA in the Netherlands.

AB - In 2003 in the Netherlands, a new methicillin-resistant Staphylococcus aureus (MRSA) strain emerged that could not be typed with Sma1 pulsed-field gel electrophoresis (NT-MRSA). The association of NT-MRSA in humans with a reservoir in animals was investigated. The frequency of NT-MRSA increased from 0% in 2002 to >21% after intensi-fied surveillance was implemented in July 2006. Geographically, NT-MRSA clustered with pig farming. A case-control study showed that carriers of NT-MRSA were more often pig or cattle farmers (pig farmers odds ratio [OR] 12.2, 95% confidence interval [CI] 3.1-48.6; cattle farmers OR 19.7, 95% CI 2.3-169.5). Molecular typing showed that the NTMRSA strains belonged to a new clonal complex, ST 398. This study shows that MRSA from an animal reservoir has recently entered the human population and is now responsible for >20% of all MRSA in the Netherlands.

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VL - 13

SP - 1834

EP - 1839

JO - Emerging infectious diseases

JF - Emerging infectious diseases

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ER -

Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans

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