Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans

Inge Van Loo; Xander Huijsdens; Edine Tiemersma; Albert De Neeling; Nienke Van De Sande-Bruinsma; Desiree Beaujean; Andreas Voss; Jan Kluytmans

doi:10.3201/eid1312.070384

Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans

Inge Van Loo, Xander Huijsdens, Edine Tiemersma, Albert De Neeling, Nienke Van De Sande-Bruinsma, Desiree Beaujean, Andreas Voss, Jan Kluytmans^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

352 Citations (Scopus)

Abstract

In 2003 in the Netherlands, a new methicillin-resistant Staphylococcus aureus (MRSA) strain emerged that could not be typed with Sma1 pulsed-field gel electrophoresis (NT-MRSA). The association of NT-MRSA in humans with a reservoir in animals was investigated. The frequency of NT-MRSA increased from 0% in 2002 to >21% after intensi-fied surveillance was implemented in July 2006. Geographically, NT-MRSA clustered with pig farming. A case-control study showed that carriers of NT-MRSA were more often pig or cattle farmers (pig farmers odds ratio [OR] 12.2, 95% confidence interval [CI] 3.1-48.6; cattle farmers OR 19.7, 95% CI 2.3-169.5). Molecular typing showed that the NTMRSA strains belonged to a new clonal complex, ST 398. This study shows that MRSA from an animal reservoir has recently entered the human population and is now responsible for >20% of all MRSA in the Netherlands.

Original language	English
Pages (from-to)	1834-1839
Number of pages	6
Journal	Emerging infectious diseases
Volume	13
Issue number	12
DOIs	https://doi.org/10.3201/eid1312.070384
Publication status	Published - Dec 2007
Externally published	Yes

Access to Document

10.3201/eid1312.070384

Cite this

@article{fbf4b8e358d44c2e814146599f14dcdc,

title = "Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans",

abstract = "In 2003 in the Netherlands, a new methicillin-resistant Staphylococcus aureus (MRSA) strain emerged that could not be typed with Sma1 pulsed-field gel electrophoresis (NT-MRSA). The association of NT-MRSA in humans with a reservoir in animals was investigated. The frequency of NT-MRSA increased from 0% in 2002 to >21% after intensi-fied surveillance was implemented in July 2006. Geographically, NT-MRSA clustered with pig farming. A case-control study showed that carriers of NT-MRSA were more often pig or cattle farmers (pig farmers odds ratio [OR] 12.2, 95% confidence interval [CI] 3.1-48.6; cattle farmers OR 19.7, 95% CI 2.3-169.5). Molecular typing showed that the NTMRSA strains belonged to a new clonal complex, ST 398. This study shows that MRSA from an animal reservoir has recently entered the human population and is now responsible for >20% of all MRSA in the Netherlands.",

author = "{Van Loo}, Inge and Xander Huijsdens and Edine Tiemersma and {De Neeling}, Albert and {Van De Sande-Bruinsma}, Nienke and Desiree Beaujean and Andreas Voss and Jan Kluytmans",

year = "2007",

month = dec,

doi = "10.3201/eid1312.070384",

language = "English",

volume = "13",

pages = "1834--1839",

journal = "Emerging infectious diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "12",

}

TY - JOUR

T1 - Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans

AU - Van Loo, Inge

AU - Huijsdens, Xander

AU - Tiemersma, Edine

AU - De Neeling, Albert

AU - Van De Sande-Bruinsma, Nienke

AU - Beaujean, Desiree

AU - Voss, Andreas

AU - Kluytmans, Jan

PY - 2007/12

Y1 - 2007/12

N2 - In 2003 in the Netherlands, a new methicillin-resistant Staphylococcus aureus (MRSA) strain emerged that could not be typed with Sma1 pulsed-field gel electrophoresis (NT-MRSA). The association of NT-MRSA in humans with a reservoir in animals was investigated. The frequency of NT-MRSA increased from 0% in 2002 to >21% after intensi-fied surveillance was implemented in July 2006. Geographically, NT-MRSA clustered with pig farming. A case-control study showed that carriers of NT-MRSA were more often pig or cattle farmers (pig farmers odds ratio [OR] 12.2, 95% confidence interval [CI] 3.1-48.6; cattle farmers OR 19.7, 95% CI 2.3-169.5). Molecular typing showed that the NTMRSA strains belonged to a new clonal complex, ST 398. This study shows that MRSA from an animal reservoir has recently entered the human population and is now responsible for >20% of all MRSA in the Netherlands.

AB - In 2003 in the Netherlands, a new methicillin-resistant Staphylococcus aureus (MRSA) strain emerged that could not be typed with Sma1 pulsed-field gel electrophoresis (NT-MRSA). The association of NT-MRSA in humans with a reservoir in animals was investigated. The frequency of NT-MRSA increased from 0% in 2002 to >21% after intensi-fied surveillance was implemented in July 2006. Geographically, NT-MRSA clustered with pig farming. A case-control study showed that carriers of NT-MRSA were more often pig or cattle farmers (pig farmers odds ratio [OR] 12.2, 95% confidence interval [CI] 3.1-48.6; cattle farmers OR 19.7, 95% CI 2.3-169.5). Molecular typing showed that the NTMRSA strains belonged to a new clonal complex, ST 398. This study shows that MRSA from an animal reservoir has recently entered the human population and is now responsible for >20% of all MRSA in the Netherlands.

UR - http://www.scopus.com/inward/record.url?scp=37049019504&partnerID=8YFLogxK

U2 - 10.3201/eid1312.070384

DO - 10.3201/eid1312.070384

M3 - Article

C2 - 18258032

AN - SCOPUS:37049019504

SN - 1080-6040

VL - 13

SP - 1834

EP - 1839

JO - Emerging infectious diseases

JF - Emerging infectious diseases

IS - 12

ER -

Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans

Abstract

Access to Document

Other files and links

Fingerprint

Cite this