@article{7baa3ab295db4641aae866ac91c507de,
title = "Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish",
abstract = "Using zebrafish to investigate microglia ontogeny during vertebrate development, Ferrero et al. find that embryonic “primitive” microglia exclusively derive from primitive macrophages, while adult “definitive” microglia originate from cmyb-dependent hematopoietic stem cells.",
keywords = "cmyb, developmental hematopoiesis, erythro-myeloid progenitors, fate mapping, hematopoietic stem cells, microglia, ontogeny, primitive macrophages",
author = "Giuliano Ferrero and Mahony, {Christopher B.} and El{\'e}onore Dupuis and Laurent Yvernogeau and {Di Ruggiero}, Elodie and Magali Miserocchi and Marianne Caron and Catherine Robin and David Traver and Bertrand, {Julien Y.} and Val{\'e}rie Wittamer",
note = "Funding Information: We thank J.-M. Vanderwinden and the LiMiF for technical support with confocal imaging, Christine Dubois for help with flow cytometry, Chantal Combepine and Naoual Azeroual for technical assistance, and Karen Ong for laboratory maintenance (D.T. lab). V.W. is an investigator of WELBIO and is also supported by grants from the Fonds National de la Recherche Scientifique (FNRS), Innoviris (BB2B Programme), and The Minerve Foundation. J.Y.B. is endorsed by a Chair in Life Sciences funded by the Gabriella Giorgi-Cavaglieri Foundation and is also funded by the Swiss National Fund (31003_166515). D.T. is supported by R21 AI124179 from the National Institutes of Health and C.R. by a European Research Council grant (ERC Project Number 220-H75001EU/HSCOrigin-309361), a TOP subsidy from NWO/ZonMw (912.15.017), and the UMC Utrecht “Regenerative Medicine & Stem Cells” Priority Research Program. G.F. received funding from UNI and FNRS fellowships, and E.D.R. received funding from a FRIA fellowship. Funding Information: We thank J.-M. Vanderwinden and the LiMiF for technical support with confocal imaging, Christine Dubois for help with flow cytometry, Chantal Combepine and Naoual Azeroual for technical assistance, and Karen Ong for laboratory maintenance (D.T. lab). V.W. is an investigator of WELBIO and is also supported by grants from the Fonds National de la Recherche Scientifique (FNRS), Innoviris (BB2B Programme), and The Minerve Foundation. J.Y.B. is endorsed by a Chair in Life Sciences funded by the Gabriella Giorgi-Cavaglieri Foundation and is also funded by the Swiss National Fund (31003_166515). D.T. is supported by R21 AI124179 from the National Institutes of Health and C.R. by a European Research Council grant (ERC Project Number 220-H75001EU/HSCOrigin-309361), a TOP subsidy from NWO/ZonMw (912.15.017), and the UMC Utrecht ?Regenerative Medicine & Stem Cells? Priority Research Program. G.F. received funding from UNI and FNRS fellowships, and E.D.R. received funding from a FRIA fellowship. Funding Information: We thank J.-M. Vanderwinden and the LiMiF for technical support with confocal imaging, Christine Dubois for help with flow cytometry, Chantal Combepine and Naoual Azeroual for technical assistance, and Karen Ong for laboratory maintenance (D.T. lab). V.W. is an investigator of WELBIO and is also supported by grants from the Fonds National de la Recherche Scientifique (FNRS) , Innoviris ( BB2B Programme ), and The Minerve Foundation . J.Y.B. is endorsed by a Chair in Life Sciences funded by the Gabriella Giorgi-Cavaglieri Foundation and is also funded by the Swiss National Fund ( 31003_166515 ). D.T. is supported by R21 AI124179 from the National Institutes of Health and C.R. by a European Research Council grant ( ERC Project Number 220-H75001EU/HSCOrigin-309361 ), a TOP subsidy from NWO/ZonMw ( 912.15.017 ), and the UMC Utrecht “Regenerative Medicine & Stem Cells” Priority Research Program. G.F. received funding from UNI and FNRS fellowships, and E.D.R. received funding from a FRIA fellowship. ",
year = "2018",
month = jul,
day = "3",
doi = "10.1016/j.celrep.2018.05.066",
language = "English",
volume = "24",
pages = "130--141",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}