Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Tineke Kardol-Hoefnagel; Danial Mohammadi Senejohnny; Elena G. Kamburova; Bram W. Wisse; Maartje L. Gruijters; Irma Joosten; Wil A. Allebes; Arnold van der Meer; Luuk B. Hilbrands; Marije C. Baas; Eric Spierings; Cornelis E. Hack; Franka E. van Reekum; Arjan D. van Zuilen; Marianne C. Verhaar; Adriaan C.A.D. Drop; Loes Plaisier; Rowena C.A. Melchers; Marc A.J. Seelen; Jan Stephan Sanders; Bouke G. Hepkema; Bart Jan Kroesen; Laura B. Bungener; Caroline Roozendaal; Marcel G.J. Tilanus; Christina E. Voorter; Lotte Wieten; Elly M. van Duijnhoven; Mariëlle A.C.J. Gelens; Maarten H.L. Christiaans; Frans J. van Ittersum; Shaikh A. Nurmohamed; Neubury M. Lardy; Wendy Swelsen; Karlijn A.M.I. van der Pant; Neelke C. van der Weerd; Ineke J.M. ten Berge; Andries Hoitsma; Paul J.M. van der Boog; Johan W. de Fijter; Michiel G.H. Betjes; Dave L. Roelen; Frans H. Claas; Frederike J. Bemelman; Sebastiaan Heidt; Henny G. Otten

doi:10.1111/tan.15297

Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Tineke Kardol-Hoefnagel^*, Danial Mohammadi Senejohnny, Elena G. Kamburova, Bram W. Wisse, Maartje L. Gruijters, Irma Joosten, Wil A. Allebes, Arnold van der Meer, Luuk B. Hilbrands, Marije C. Baas, Eric Spierings, Cornelis E. Hack, Franka E. van Reekum, Arjan D. van Zuilen, Marianne C. Verhaar, Adriaan C.A.D. Drop, Loes Plaisier, Rowena C.A. Melchers, Marc A.J. Seelen, Jan Stephan SandersBouke G. Hepkema, Bart Jan Kroesen, Laura B. Bungener, Caroline Roozendaal, Marcel G.J. Tilanus, Christina E. Voorter, Lotte Wieten, Elly M. van Duijnhoven, Mariëlle A.C.J. Gelens, Maarten H.L. Christiaans, Frans J. van Ittersum, Shaikh A. Nurmohamed, Neubury M. Lardy, Wendy Swelsen, Karlijn A.M.I. van der Pant, Neelke C. van der Weerd, Ineke J.M. ten Berge, Andries Hoitsma, Paul J.M. van der Boog, Johan W. de Fijter, Michiel G.H. Betjes, Dave L. Roelen, Frans H. Claas, Frederike J. Bemelman, Sebastiaan Heidt, Henny G. Otten^*

^*Corresponding author for this work

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Abstract

In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.

Original language	English
Article number	e15297
Number of pages	6
Journal	HLA
Volume	103
Issue number	1
DOIs	https://doi.org/10.1111/tan.15297
Publication status	Published - Jan 2024

Keywords

DESA
Ellipro scores
kidney transplantation

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10.1111/tan.15297Licence: CC BY-NC-ND

HLA - 2023 - Kardol‐Hoefnagel - Ellipro scores of donor epitope specific HLA antibodies are not associated with kidneyFinal published version, 1.08 MBLicence: CC BY-NC-ND

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Kardol-Hoefnagel, T., Senejohnny, D. M., Kamburova, E. G., Wisse, B. W., Gruijters, M. L., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Drop, A. C. A. D., Plaisier, L., Melchers, R. C. A., Seelen, M. A. J., ... Otten, H. G. (2024). Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival. HLA, 103(1), Article e15297. https://doi.org/10.1111/tan.15297

@article{ea1adccf610543a4a4cb017f16673e32,

title = "Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival",

abstract = "In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.",

keywords = "DESA, Ellipro scores, kidney transplantation",

author = "Tineke Kardol-Hoefnagel and Senejohnny, {Danial Mohammadi} and Kamburova, {Elena G.} and Wisse, {Bram W.} and Gruijters, {Maartje L.} and Irma Joosten and Allebes, {Wil A.} and {van der Meer}, Arnold and Hilbrands, {Luuk B.} and Baas, {Marije C.} and Eric Spierings and Hack, {Cornelis E.} and {van Reekum}, {Franka E.} and {van Zuilen}, {Arjan D.} and Verhaar, {Marianne C.} and Drop, {Adriaan C.A.D.} and Loes Plaisier and Melchers, {Rowena C.A.} and Seelen, {Marc A.J.} and Sanders, {Jan Stephan} and Hepkema, {Bouke G.} and Kroesen, {Bart Jan} and Bungener, {Laura B.} and Caroline Roozendaal and Tilanus, {Marcel G.J.} and Voorter, {Christina E.} and Lotte Wieten and {van Duijnhoven}, {Elly M.} and Gelens, {Mari{\"e}lle A.C.J.} and Christiaans, {Maarten H.L.} and {van Ittersum}, {Frans J.} and Nurmohamed, {Shaikh A.} and Lardy, {Neubury M.} and Wendy Swelsen and {van der Pant}, {Karlijn A.M.I.} and {van der Weerd}, {Neelke C.} and {ten Berge}, {Ineke J.M.} and Andries Hoitsma and {van der Boog}, {Paul J.M.} and {de Fijter}, {Johan W.} and Betjes, {Michiel G.H.} and Roelen, {Dave L.} and Claas, {Frans H.} and Bemelman, {Frederike J.} and Sebastiaan Heidt and Otten, {Henny G.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. HLA: Immune Response Genetics published by John Wiley & Sons Ltd.",

year = "2024",

month = jan,

doi = "10.1111/tan.15297",

language = "English",

volume = "103",

number = "1",

}

Kardol-Hoefnagel, T, Senejohnny, DM, Kamburova, EG, Wisse, BW, Gruijters, ML, Joosten, I, Allebes, WA, van der Meer, A, Hilbrands, LB, Baas, MC, Spierings, E, Hack, CE, van Reekum, FE, van Zuilen, AD , Verhaar, MC, Drop, ACAD, Plaisier, L, Melchers, RCA, Seelen, MAJ, Sanders, JS, Hepkema, BG, Kroesen, BJ, Bungener, LB, Roozendaal, C, Tilanus, MGJ, Voorter, CE, Wieten, L, van Duijnhoven, EM, Gelens, MACJ, Christiaans, MHL, van Ittersum, FJ, Nurmohamed, SA, Lardy, NM, Swelsen, W, van der Pant, KAMI, van der Weerd, NC, ten Berge, IJM, Hoitsma, A, van der Boog, PJM, de Fijter, JW, Betjes, MGH, Roelen, DL, Claas, FH, Bemelman, FJ, Heidt, S & Otten, HG 2024, 'Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival', HLA, vol. 103, no. 1, e15297. https://doi.org/10.1111/tan.15297

TY - JOUR

T1 - Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

AU - Kardol-Hoefnagel, Tineke

AU - Senejohnny, Danial Mohammadi

AU - Kamburova, Elena G.

AU - Wisse, Bram W.

AU - Gruijters, Maartje L.

AU - Joosten, Irma

AU - Allebes, Wil A.

AU - van der Meer, Arnold

AU - Hilbrands, Luuk B.

AU - Baas, Marije C.

AU - Spierings, Eric

AU - Hack, Cornelis E.

AU - van Reekum, Franka E.

AU - van Zuilen, Arjan D.

AU - Verhaar, Marianne C.

AU - Drop, Adriaan C.A.D.

AU - Plaisier, Loes

AU - Melchers, Rowena C.A.

AU - Seelen, Marc A.J.

AU - Sanders, Jan Stephan

AU - Hepkema, Bouke G.

AU - Kroesen, Bart Jan

AU - Bungener, Laura B.

AU - Roozendaal, Caroline

AU - Tilanus, Marcel G.J.

AU - Voorter, Christina E.

AU - Wieten, Lotte

AU - van Duijnhoven, Elly M.

AU - Gelens, Mariëlle A.C.J.

AU - Christiaans, Maarten H.L.

AU - van Ittersum, Frans J.

AU - Nurmohamed, Shaikh A.

AU - Lardy, Neubury M.

AU - Swelsen, Wendy

AU - van der Pant, Karlijn A.M.I.

AU - van der Weerd, Neelke C.

AU - ten Berge, Ineke J.M.

AU - Hoitsma, Andries

AU - van der Boog, Paul J.M.

AU - de Fijter, Johan W.

AU - Betjes, Michiel G.H.

AU - Roelen, Dave L.

AU - Claas, Frans H.

AU - Bemelman, Frederike J.

AU - Heidt, Sebastiaan

AU - Otten, Henny G.

PY - 2024/1

Y1 - 2024/1

N2 - In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.

AB - In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.

KW - DESA

KW - Ellipro scores

KW - kidney transplantation

UR - http://www.scopus.com/inward/record.url?scp=85181226604&partnerID=8YFLogxK

U2 - 10.1111/tan.15297

DO - 10.1111/tan.15297

M3 - Article

AN - SCOPUS:85181226604

SN - 2059-2302

VL - 103

JO - HLA

JF - HLA

IS - 1

M1 - e15297

ER -

Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

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