Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder

C S de Kloet; E Vermetten; E Geuze; E G W M Lentjes; C J Heijnen; G K Stalla; H G M Westenberg

doi:10.1016/S0079-6123(07)67025-3

Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder

C S de Kloet, E Vermetten, E Geuze, E G W M Lentjes, C J Heijnen, G K Stalla, H G M Westenberg

Psychiatry

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Posttraumatic stress disorder (PTSD) is associated with alterations in corticotrophin-releasing hormone (CRH) secretion. Plasma CRH levels, which are easily acquired, might serve as a predictor of hypothalamic CRH levels. Assessment of plasma CRH, adrenocorticotrophin hormone (ACTH), and cortisol levels in 31 veterans with PTSD, 30 traumatized veterans without PTSD matched on age, year, and region of deployment (traumacontrols), and 28 age-matched healthy controls (HCs) was carried out. Plasma CRH levels were higher in PTSD patients compared to both HCs (p=0.005) and traumacontrols (p=0.007). This led to our conclusion, that elevated plasma CRH levels are specifically related to PTSD and not to exposure to traumatic stress during deployment.

Original language	English
Pages (from-to)	287-91
Number of pages	5
Journal	Progress in Brain Research
Volume	167
DOIs	https://doi.org/10.1016/S0079-6123(07)67025-3
Publication status	Published - 2008

Keywords

Adult
Corticotropin-Releasing Hormone/blood
Female
Humans
Male
Psychiatric Status Rating Scales
Stress Disorders, Post-Traumatic/blood
Veterans

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10.1016/S0079-6123(07)67025-3

Cite this

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title = "Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder",

abstract = "Posttraumatic stress disorder (PTSD) is associated with alterations in corticotrophin-releasing hormone (CRH) secretion. Plasma CRH levels, which are easily acquired, might serve as a predictor of hypothalamic CRH levels. Assessment of plasma CRH, adrenocorticotrophin hormone (ACTH), and cortisol levels in 31 veterans with PTSD, 30 traumatized veterans without PTSD matched on age, year, and region of deployment (traumacontrols), and 28 age-matched healthy controls (HCs) was carried out. Plasma CRH levels were higher in PTSD patients compared to both HCs (p=0.005) and traumacontrols (p=0.007). This led to our conclusion, that elevated plasma CRH levels are specifically related to PTSD and not to exposure to traumatic stress during deployment.",

keywords = "Adult, Corticotropin-Releasing Hormone/blood, Female, Humans, Male, Psychiatric Status Rating Scales, Stress Disorders, Post-Traumatic/blood, Veterans",

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doi = "10.1016/S0079-6123(07)67025-3",

language = "English",

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AU - de Kloet, C S

AU - Vermetten, E

AU - Geuze, E

AU - Lentjes, E G W M

AU - Heijnen, C J

AU - Stalla, G K

AU - Westenberg, H G M

PY - 2008

Y1 - 2008

N2 - Posttraumatic stress disorder (PTSD) is associated with alterations in corticotrophin-releasing hormone (CRH) secretion. Plasma CRH levels, which are easily acquired, might serve as a predictor of hypothalamic CRH levels. Assessment of plasma CRH, adrenocorticotrophin hormone (ACTH), and cortisol levels in 31 veterans with PTSD, 30 traumatized veterans without PTSD matched on age, year, and region of deployment (traumacontrols), and 28 age-matched healthy controls (HCs) was carried out. Plasma CRH levels were higher in PTSD patients compared to both HCs (p=0.005) and traumacontrols (p=0.007). This led to our conclusion, that elevated plasma CRH levels are specifically related to PTSD and not to exposure to traumatic stress during deployment.

AB - Posttraumatic stress disorder (PTSD) is associated with alterations in corticotrophin-releasing hormone (CRH) secretion. Plasma CRH levels, which are easily acquired, might serve as a predictor of hypothalamic CRH levels. Assessment of plasma CRH, adrenocorticotrophin hormone (ACTH), and cortisol levels in 31 veterans with PTSD, 30 traumatized veterans without PTSD matched on age, year, and region of deployment (traumacontrols), and 28 age-matched healthy controls (HCs) was carried out. Plasma CRH levels were higher in PTSD patients compared to both HCs (p=0.005) and traumacontrols (p=0.007). This led to our conclusion, that elevated plasma CRH levels are specifically related to PTSD and not to exposure to traumatic stress during deployment.

KW - Adult

KW - Corticotropin-Releasing Hormone/blood

KW - Female

KW - Humans

KW - Male

KW - Psychiatric Status Rating Scales

KW - Stress Disorders, Post-Traumatic/blood

KW - Veterans

U2 - 10.1016/S0079-6123(07)67025-3

DO - 10.1016/S0079-6123(07)67025-3

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SN - 0079-6123

VL - 167

SP - 287

EP - 291

JO - Progress in Brain Research

JF - Progress in Brain Research

ER -

Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder

Abstract

Keywords

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