Elective tolerance to behavioral effects of neurotensin

G. J.E. Rinkel; E. C. Hoeke; Tj B. van Wimersma Greidanus

doi:10.1016/0031-9384(83)90067-7

Elective tolerance to behavioral effects of neurotensin

G. J.E. Rinkel
, E. C. Hoeke
, Tj B. van Wimersma Greidanus^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

Neurotensin reduces locomotor activity in an open field situation as well as responsiveness to electric footshock. Repeated injections of neurotensin in combination with repeated testing of locomotor activity in the open field as well as repeated injections of neurotensin without such testing in the open field do not result in a reduction of locomotor activity. These findings make development of tolerance to this behavioral effect of neurotensin likely. Such a development of tolerance to neurotensin is not observed for the effect on responsiveness to electric footshock.

Original language	English
Pages (from-to)	467-470
Number of pages	4
Journal	Physiology and Behavior
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/0031-9384(83)90067-7
Publication status	Published - 1 Jan 1983

Keywords

Locomotor activity
Neurotensin
Open field behavior
Responsiveness to electric footshock
Tolerance

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10.1016/0031-9384(83)90067-7

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title = "Elective tolerance to behavioral effects of neurotensin",

abstract = "Neurotensin reduces locomotor activity in an open field situation as well as responsiveness to electric footshock. Repeated injections of neurotensin in combination with repeated testing of locomotor activity in the open field as well as repeated injections of neurotensin without such testing in the open field do not result in a reduction of locomotor activity. These findings make development of tolerance to this behavioral effect of neurotensin likely. Such a development of tolerance to neurotensin is not observed for the effect on responsiveness to electric footshock.",

keywords = "Locomotor activity, Neurotensin, Open field behavior, Responsiveness to electric footshock, Tolerance",

author = "Rinkel, \{G. J.E.\} and Hoeke, \{E. C.\} and \{van Wimersma Greidanus\}, \{Tj B.\}",

year = "1983",

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T1 - Elective tolerance to behavioral effects of neurotensin

AU - Rinkel, G. J.E.

AU - Hoeke, E. C.

AU - van Wimersma Greidanus, Tj B.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Neurotensin reduces locomotor activity in an open field situation as well as responsiveness to electric footshock. Repeated injections of neurotensin in combination with repeated testing of locomotor activity in the open field as well as repeated injections of neurotensin without such testing in the open field do not result in a reduction of locomotor activity. These findings make development of tolerance to this behavioral effect of neurotensin likely. Such a development of tolerance to neurotensin is not observed for the effect on responsiveness to electric footshock.

AB - Neurotensin reduces locomotor activity in an open field situation as well as responsiveness to electric footshock. Repeated injections of neurotensin in combination with repeated testing of locomotor activity in the open field as well as repeated injections of neurotensin without such testing in the open field do not result in a reduction of locomotor activity. These findings make development of tolerance to this behavioral effect of neurotensin likely. Such a development of tolerance to neurotensin is not observed for the effect on responsiveness to electric footshock.

KW - Locomotor activity

KW - Neurotensin

KW - Open field behavior

KW - Responsiveness to electric footshock

KW - Tolerance

UR - https://www.scopus.com/pages/publications/0020573092

U2 - 10.1016/0031-9384(83)90067-7

DO - 10.1016/0031-9384(83)90067-7

M3 - Article

C2 - 6657768

AN - SCOPUS:0020573092

SN - 0031-9384

VL - 31

SP - 467

EP - 470

JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 4

ER -

Elective tolerance to behavioral effects of neurotensin

Abstract

Keywords

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