TY - JOUR
T1 - ELAPSS score for prediction of risk of growth of unruptured intracranial aneurysms
AU - Backes, Daan
AU - Rinkel, Gabriel J.E.
AU - Greving, Jacoba P.
AU - Velthuis, Birgitta K.
AU - Murayama, Yuichi
AU - Takao, Hiroyuki
AU - Ishibashi, Toshihiro
AU - Igase, Michiya
AU - terBrugge, Karel G.
AU - Agid, Ronit
AU - Jääskeläinen, Juha E
AU - Lindgren, Antti E.
AU - Koivisto, Timo
AU - von Und Zu Fraunberg, Mikael
AU - Matsubara, Shunji
AU - Moroi, Junta
AU - Wong, George K C
AU - Abrigo, Jill M
AU - Igase, Keiji
AU - Matsumoto, Katsumi
AU - Wermer, Marieke J H
AU - van Walderveen, Marianne A A
AU - Algra, Ale
AU - Vergouwen, Mervyn D.I.
N1 - Publisher Copyright:
© 2017 American Academy of Neurology.
PY - 2017/4/25
Y1 - 2017/4/25
N2 - Objective: To develop a risk score that estimates 3-year and 5-year absolute risks for aneurysm growth. Methods: From 10 cohorts of patients with unruptured intracranial aneurysms and follow-up imaging, we pooled individual data on sex, population, age, hypertension, history of subarachnoid hemorrhage, and aneurysm location, size, aspect ratio, and shape but not on smoking during follow-up and family history of intracranial aneurysms in 1,507 patients with 1,909 unruptured intracranial aneurysms and used aneurysm growth as outcome. With aneurysm-based multivariable Cox regression analysis, we determined predictors for aneurysm growth, which were presented as a risk score to calculate 3-year and 5-year risks for aneurysm growth by risk factor status. Results: Aneurysm growth occurred in 257 patients (17%) and 267 aneurysms (14%) during 5,782 patient-years of follow-up. Predictors for aneurysm growth were earlier subarachnoid hemorrhage, location of the aneurysm, age .60 years, population, size of the aneurysm, and shape of the aneurysm (ELAPSS). The 3-year growth risk ranged from ,5% to .42%and the 5-year growth risk from ,9% to .60%, depending on the risk factor status. Conclusions: The ELAPSS score consists of 6 easily retrievable predictors and can help physicians in decision making on the need for and timing of follow-up imaging in patients with unruptured intracranial aneurysms.
AB - Objective: To develop a risk score that estimates 3-year and 5-year absolute risks for aneurysm growth. Methods: From 10 cohorts of patients with unruptured intracranial aneurysms and follow-up imaging, we pooled individual data on sex, population, age, hypertension, history of subarachnoid hemorrhage, and aneurysm location, size, aspect ratio, and shape but not on smoking during follow-up and family history of intracranial aneurysms in 1,507 patients with 1,909 unruptured intracranial aneurysms and used aneurysm growth as outcome. With aneurysm-based multivariable Cox regression analysis, we determined predictors for aneurysm growth, which were presented as a risk score to calculate 3-year and 5-year risks for aneurysm growth by risk factor status. Results: Aneurysm growth occurred in 257 patients (17%) and 267 aneurysms (14%) during 5,782 patient-years of follow-up. Predictors for aneurysm growth were earlier subarachnoid hemorrhage, location of the aneurysm, age .60 years, population, size of the aneurysm, and shape of the aneurysm (ELAPSS). The 3-year growth risk ranged from ,5% to .42%and the 5-year growth risk from ,9% to .60%, depending on the risk factor status. Conclusions: The ELAPSS score consists of 6 easily retrievable predictors and can help physicians in decision making on the need for and timing of follow-up imaging in patients with unruptured intracranial aneurysms.
UR - http://www.scopus.com/inward/record.url?scp=85019788168&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000003865
DO - 10.1212/WNL.0000000000003865
M3 - Article
C2 - 28363976
SN - 0028-3878
VL - 88
SP - 1600
EP - 1606
JO - Neurology
JF - Neurology
IS - 17
ER -