TY - JOUR
T1 - Efficacy of the eHealth application Oncokompas, facilitating incurably ill cancer patients to self-manage their palliative care needs
T2 - A randomized controlled trial
AU - Schuit, Anouk S
AU - Holtmaat, Karen
AU - Lissenberg-Witte, Birgit I
AU - Eerenstein, Simone E J
AU - Zijlstra, Josée M
AU - Eeltink, Corien
AU - Becker-Commissaris, Annemarie
AU - van Zuylen, Lia
AU - van Linde, Myra E
AU - Menke-van der Houven van Oordt, C Willemien
AU - Sommeijer, Dirkje W
AU - Verbeek, Nol
AU - Bosscha, Koop
AU - Tewarie, Rishi Nandoe
AU - Sedee, Robert-Jan
AU - de Bree, Remco
AU - de Graeff, Alexander
AU - de Vos, Filip
AU - Cuijpers, Pim
AU - Verdonck-de Leeuw, Irma M
N1 - Funding Information:
AS, KH, BLW, PC, and IVdL contributed to the design of the study. AS, KH, and IVdL coordinated the study. AS, KH, SE, JZ, CE, ABC, LvZ, MEvL, WM, DWS, NV, KB, RNT, RJS, RdB, AdG, FdV, PC, and IVdL contributed to the data collection. AS, BLW, KH, PC, and IVdL performed the data analyses. AS, KH, PC, and IVdL drafted the manuscript. All authors critically revised the manuscript. All authors read and approved the final manuscript. Not applicable. Taking legal restrictions into account, the data collected for this study are available on request via the corresponding author up to 15 years after the end of the study. This study was approved by the Medical Ethics Committee of VU University Medical Center (2018.224). All patients provided written informed consent before study participation.
Funding Information:
IVdL reports grants from the Netherlands Organization for Health Research and Development (ZonMw), the Dutch Cancer Society (KWF Kankerbestrijding), Bristol Myers Squibb, Danone Ecofund/Nutricia. ABC reports grants from Roche. FdV reports grants from Foundation STOPbraintumors.org and AbbVIe, BMS, Novartis, EORTC, Vaximm and BioClin Therapeutics. FdV reports participation on a DSMB during the conduct of this study, and leaderships or fiduciary roles in other boards and commissions. All other authors declare no competing interests.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/7
Y1 - 2022/7
N2 - Background: Many patients with incurable cancer have symptoms affecting their health-related quality of life. The eHealth application 'Oncokompas' supports patients to take an active role in managing their palliative care needs, to reduce symptoms and improve health-related quality of life (HRQOL). This randomized controlled trial was conducted to determine the efficacy of Oncokompas compared to care as usual among incurably ill cancer patients with a life expectancy of more than three months.Methods: Patients were recruited in six hospitals in the Netherlands. Eligible patients were randomly assigned to the intervention (direct access to Oncokompas) or the control group (access to Oncokompas after three months). The primary outcome measure was patient activation (i.e., patients' knowledge, skills and confidence for self-management). Secondary outcomes were general self-efficacy and HRQOL. Measures were assessed at baseline, two weeks after randomization, and three months after the baseline measurement. Linear mixed models were used to compare longitudinal changes between both groups from baseline to the three-month follow-up.Findings: In total, 219 patients were eligible of which 138 patients completed the baseline questionnaire (response rate 63%), and were randomized to the intervention (69) or control group (69). There were no significant differences between the intervention and control group over time in patient activation (estimated difference in change T0-T2; 1·8 (90% CI: -1·0 to 4·7)), neither in general self-efficacy and HRQOL. Of the patients in the intervention group who activated their account, 74% used Oncokompas as intended. The course of patient activation, general self-efficacy, and HRQOL was not significantly different between patients who used Oncokompas as intended versus those who did not.Interpretation: Among incurably ill cancer patients with a life expectancy of more than three months and recruited in the hospital setting, Oncokompas did not significantly improve patient activation, self-efficacy, or HRQOL.Funding: ZonMw, Netherlands Organization for Health Research and Development (844001105).
AB - Background: Many patients with incurable cancer have symptoms affecting their health-related quality of life. The eHealth application 'Oncokompas' supports patients to take an active role in managing their palliative care needs, to reduce symptoms and improve health-related quality of life (HRQOL). This randomized controlled trial was conducted to determine the efficacy of Oncokompas compared to care as usual among incurably ill cancer patients with a life expectancy of more than three months.Methods: Patients were recruited in six hospitals in the Netherlands. Eligible patients were randomly assigned to the intervention (direct access to Oncokompas) or the control group (access to Oncokompas after three months). The primary outcome measure was patient activation (i.e., patients' knowledge, skills and confidence for self-management). Secondary outcomes were general self-efficacy and HRQOL. Measures were assessed at baseline, two weeks after randomization, and three months after the baseline measurement. Linear mixed models were used to compare longitudinal changes between both groups from baseline to the three-month follow-up.Findings: In total, 219 patients were eligible of which 138 patients completed the baseline questionnaire (response rate 63%), and were randomized to the intervention (69) or control group (69). There were no significant differences between the intervention and control group over time in patient activation (estimated difference in change T0-T2; 1·8 (90% CI: -1·0 to 4·7)), neither in general self-efficacy and HRQOL. Of the patients in the intervention group who activated their account, 74% used Oncokompas as intended. The course of patient activation, general self-efficacy, and HRQOL was not significantly different between patients who used Oncokompas as intended versus those who did not.Interpretation: Among incurably ill cancer patients with a life expectancy of more than three months and recruited in the hospital setting, Oncokompas did not significantly improve patient activation, self-efficacy, or HRQOL.Funding: ZonMw, Netherlands Organization for Health Research and Development (844001105).
KW - eHealth
KW - Incurable cancer
KW - Palliative care
KW - Psychosocial oncology
KW - Supportive care
UR - https://www.scopus.com/pages/publications/85129628906
U2 - 10.1016/j.lanepe.2022.100390
DO - 10.1016/j.lanepe.2022.100390
M3 - Article
C2 - 35496496
VL - 18
SP - 1
EP - 11
JO - The Lancet Regional Health - Europe
JF - The Lancet Regional Health - Europe
M1 - 100390
ER -