Efficacy and safety of SARS-CoV-2 vaccination in pregnancy to prevent COVID-19 in mothers and early infancy

Odette de Bruin; Emily Wem Phijffer; Fariba Ahmadizar; Nicoline At Van der Maas; Joanne G Wildenbeest; Miriam Cjm Sturkenboom; Louis J Bont; Carlos E Durán; Kitty Wm Bloemenkamp

doi:10.1002/14651858.CD015785

Efficacy and safety of SARS-CoV-2 vaccination in pregnancy to prevent COVID-19 in mothers and early infancy

Odette de Bruin^*
, Emily Wem Phijffer
, Fariba Ahmadizar
, Nicoline At Van der Maas
, Joanne G Wildenbeest
, Miriam Cjm Sturkenboom
, Louis J Bont
, Carlos E Durán
, Kitty Wm Bloemenkamp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of SARS-CoV-2 vaccination during pregnancy, versus placebo or no vaccination during pregnancy, for preventing COVID-19 disease in mothers and infants.

Original language	English
Article number	CD015785
Pages (from-to)	1-12
Number of pages	12
Journal	The Cochrane database of systematic reviews
Volume	2025
Issue number	2
DOIs	https://doi.org/10.1002/14651858.CD015785
Publication status	Published - 26 Feb 2025

Keywords

COVID-19 Vaccines/administration & dosage
COVID-19/prevention & control
Female
Humans
Infant
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious/prevention & control
Randomized Controlled Trials as Topic
SARS-CoV-2/immunology
Vaccination

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Bruin_et_al-2025-Cochrane_Database_of_Systematic_ReviewsFinal published version, 183 KBLicence: CC BY-NC

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de Bruin, O., Phijffer, E. W., Ahmadizar, F., Van der Maas, N. A., Wildenbeest, J. G., Sturkenboom, M. C., Bont, L. J., Durán, C. E., & Bloemenkamp, K. W. (2025). Efficacy and safety of SARS-CoV-2 vaccination in pregnancy to prevent COVID-19 in mothers and early infancy. The Cochrane database of systematic reviews, 2025(2), 1-12. Article CD015785. https://doi.org/10.1002/14651858.CD015785

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title = "Efficacy and safety of SARS-CoV-2 vaccination in pregnancy to prevent COVID-19 in mothers and early infancy",

abstract = "Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of SARS-CoV-2 vaccination during pregnancy, versus placebo or no vaccination during pregnancy, for preventing COVID-19 disease in mothers and infants.",

keywords = "COVID-19 Vaccines/administration \& dosage, COVID-19/prevention \& control, Female, Humans, Infant, Infant, Newborn, Pregnancy, Pregnancy Complications, Infectious/prevention \& control, Randomized Controlled Trials as Topic, SARS-CoV-2/immunology, Vaccination",

author = "\{de Bruin\}, Odette and Phijffer, \{Emily Wem\} and Fariba Ahmadizar and \{Van der Maas\}, \{Nicoline At\} and Wildenbeest, \{Joanne G\} and Sturkenboom, \{Miriam Cjm\} and Bont, \{Louis J\} and Dur{\'a}n, \{Carlos E\} and Bloemenkamp, \{Kitty Wm\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 The Authors. Cochrane Database of Systematic Reviews published by John Wiley \& Sons, Ltd. on behalf of The Cochrane Collaboration.",

year = "2025",

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doi = "10.1002/14651858.CD015785",

language = "English",

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de Bruin, O, Phijffer, EW, Ahmadizar, F, Van der Maas, NA, Wildenbeest, JG , Sturkenboom, MC , Bont, LJ , Durán, CE & Bloemenkamp, KW 2025, 'Efficacy and safety of SARS-CoV-2 vaccination in pregnancy to prevent COVID-19 in mothers and early infancy', The Cochrane database of systematic reviews, vol. 2025, no. 2, CD015785, pp. 1-12. https://doi.org/10.1002/14651858.CD015785

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T1 - Efficacy and safety of SARS-CoV-2 vaccination in pregnancy to prevent COVID-19 in mothers and early infancy

AU - de Bruin, Odette

AU - Phijffer, Emily Wem

AU - Ahmadizar, Fariba

AU - Van der Maas, Nicoline At

AU - Wildenbeest, Joanne G

AU - Sturkenboom, Miriam Cjm

AU - Bont, Louis J

AU - Durán, Carlos E

AU - Bloemenkamp, Kitty Wm

PY - 2025/2/26

Y1 - 2025/2/26

N2 - Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of SARS-CoV-2 vaccination during pregnancy, versus placebo or no vaccination during pregnancy, for preventing COVID-19 disease in mothers and infants.

AB - Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of SARS-CoV-2 vaccination during pregnancy, versus placebo or no vaccination during pregnancy, for preventing COVID-19 disease in mothers and infants.

KW - COVID-19 Vaccines/administration & dosage

KW - COVID-19/prevention & control

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Pregnancy

KW - Pregnancy Complications, Infectious/prevention & control

KW - Randomized Controlled Trials as Topic

KW - SARS-CoV-2/immunology

KW - Vaccination

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U2 - 10.1002/14651858.CD015785

DO - 10.1002/14651858.CD015785

M3 - Article

C2 - 40008623

SN - 1469-493X

VL - 2025

SP - 1

EP - 12

JO - The Cochrane database of systematic reviews

JF - The Cochrane database of systematic reviews

IS - 2

M1 - CD015785

ER -

Efficacy and safety of SARS-CoV-2 vaccination in pregnancy to prevent COVID-19 in mothers and early infancy

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