Effects of sub-chronic nitrate exposure on the thyroidal function in humans

C. C. Hunault; A. C. Lambers; T. T. Mensinga; J. W. van Isselt; H. P F Koppeschaar; J. Meulenbelt

doi:10.1016/j.toxlet.2007.09.010

Effects of sub-chronic nitrate exposure on the thyroidal function in humans

C. C. Hunault^*, A. C. Lambers, T. T. Mensinga, J. W. van Isselt, H. P F Koppeschaar, J. Meulenbelt

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

No experimental data exist on the thyroid toxicity of nitrate among humans. We aimed to show that no significant antithyroid effect could be observed after exposure to a three times the acceptable daily intake of nitrate in humans. In a randomized controlled non-inferiority trial, 10 volunteers received 15 mg/kg sodium nitrate during 28 days whereas 10 control participants received distilled water. We performed 5- and 24-h measurements of thyroidal ¹³¹I uptake (RAIU) before and at the end of the exposure period. Thyroid hormone plasma concentrations of T3, rT3, T4, TSH were also measured prior to and after exposure. Differences in RAIU between the intervention and the control groups at 4 weeks were 3.4% (95% confidence interval -0.5 to 7.3, and 4.8% (95% confidence interval -1.4 to 11.0, respectively, for the 5- and 24-h RAIU measurement. Plasma concentrations of thyroid hormones stayed normal. In conclusion, no significant effects on thyroidal ¹³¹I uptake and thyroid hormones plasma concentrations were observed after sub-chronic exposition to 15 mg/kg sodium nitrate among humans. © 2007 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	64-70
Number of pages	7
Journal	Toxicology Letters
Volume	175
Issue number	1-3
DOIs	https://doi.org/10.1016/j.toxlet.2007.09.010
Publication status	Published - 10 Dec 2007

Keywords

Humans
Nitrate exposure
Thyroid gland function

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10.1016/j.toxlet.2007.09.010

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title = "Effects of sub-chronic nitrate exposure on the thyroidal function in humans",

abstract = "No experimental data exist on the thyroid toxicity of nitrate among humans. We aimed to show that no significant antithyroid effect could be observed after exposure to a three times the acceptable daily intake of nitrate in humans. In a randomized controlled non-inferiority trial, 10 volunteers received 15 mg/kg sodium nitrate during 28 days whereas 10 control participants received distilled water. We performed 5- and 24-h measurements of thyroidal 131I uptake (RAIU) before and at the end of the exposure period. Thyroid hormone plasma concentrations of T3, rT3, T4, TSH were also measured prior to and after exposure. Differences in RAIU between the intervention and the control groups at 4 weeks were 3.4\% (95\% confidence interval -0.5 to 7.3, and 4.8\% (95\% confidence interval -1.4 to 11.0, respectively, for the 5- and 24-h RAIU measurement. Plasma concentrations of thyroid hormones stayed normal. In conclusion, no significant effects on thyroidal 131I uptake and thyroid hormones plasma concentrations were observed after sub-chronic exposition to 15 mg/kg sodium nitrate among humans. {\textcopyright} 2007 Elsevier Ireland Ltd. All rights reserved.",

keywords = "Humans, Nitrate exposure, Thyroid gland function",

author = "Hunault, \{C. C.\} and Lambers, \{A. C.\} and Mensinga, \{T. T.\} and \{van Isselt\}, \{J. W.\} and Koppeschaar, \{H. P F\} and J. Meulenbelt",

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doi = "10.1016/j.toxlet.2007.09.010",

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AU - Hunault, C. C.

AU - Lambers, A. C.

AU - Mensinga, T. T.

AU - van Isselt, J. W.

AU - Koppeschaar, H. P F

AU - Meulenbelt, J.

PY - 2007/12/10

Y1 - 2007/12/10

N2 - No experimental data exist on the thyroid toxicity of nitrate among humans. We aimed to show that no significant antithyroid effect could be observed after exposure to a three times the acceptable daily intake of nitrate in humans. In a randomized controlled non-inferiority trial, 10 volunteers received 15 mg/kg sodium nitrate during 28 days whereas 10 control participants received distilled water. We performed 5- and 24-h measurements of thyroidal 131I uptake (RAIU) before and at the end of the exposure period. Thyroid hormone plasma concentrations of T3, rT3, T4, TSH were also measured prior to and after exposure. Differences in RAIU between the intervention and the control groups at 4 weeks were 3.4% (95% confidence interval -0.5 to 7.3, and 4.8% (95% confidence interval -1.4 to 11.0, respectively, for the 5- and 24-h RAIU measurement. Plasma concentrations of thyroid hormones stayed normal. In conclusion, no significant effects on thyroidal 131I uptake and thyroid hormones plasma concentrations were observed after sub-chronic exposition to 15 mg/kg sodium nitrate among humans. © 2007 Elsevier Ireland Ltd. All rights reserved.

AB - No experimental data exist on the thyroid toxicity of nitrate among humans. We aimed to show that no significant antithyroid effect could be observed after exposure to a three times the acceptable daily intake of nitrate in humans. In a randomized controlled non-inferiority trial, 10 volunteers received 15 mg/kg sodium nitrate during 28 days whereas 10 control participants received distilled water. We performed 5- and 24-h measurements of thyroidal 131I uptake (RAIU) before and at the end of the exposure period. Thyroid hormone plasma concentrations of T3, rT3, T4, TSH were also measured prior to and after exposure. Differences in RAIU between the intervention and the control groups at 4 weeks were 3.4% (95% confidence interval -0.5 to 7.3, and 4.8% (95% confidence interval -1.4 to 11.0, respectively, for the 5- and 24-h RAIU measurement. Plasma concentrations of thyroid hormones stayed normal. In conclusion, no significant effects on thyroidal 131I uptake and thyroid hormones plasma concentrations were observed after sub-chronic exposition to 15 mg/kg sodium nitrate among humans. © 2007 Elsevier Ireland Ltd. All rights reserved.

KW - Humans

KW - Nitrate exposure

KW - Thyroid gland function

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DO - 10.1016/j.toxlet.2007.09.010

M3 - Article

C2 - 17980977

SN - 0378-4274

VL - 175

SP - 64

EP - 70

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1-3

ER -

Effects of sub-chronic nitrate exposure on the thyroidal function in humans

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