Effects of autofluorescence imaging on detection and treatment of early neoplasia in patients with Barrett's esophagus

David F Boerwinkel, Jasmin A Holz, Mohammed A Kara, Sybren L Meijer, Michael B Wallace, Louis-Michel Wong Kee Song, Krish Ragunath, Herbert C Wolfsen, Prasad G Iyer, Kenneth K Wang, Bas L Weusten, Maurice C Aalders, Wouter L Curvers, Jacques J G H M Bergman

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND & AIMS: Studies have reported that autofluorescence imaging (AFI) increases targeted detection of high-grade intraepithelial neoplasia (HGIN) and intramucosal cancer (IMC) in patients with Barrett's esophagus (BE). We analyzed data from trials to assess the clinical relevance of AFI-detected lesions.

METHODS: We collected information on 371 patients with BE, along with endoscopy and histology findings, from databases of 5 prospective studies of AFI (mean age, 65 years; 305 male). We compared these data with outcomes of treatment and follow-up. Study end points included the diagnostic value of AFI (proportion of surveillance patients with HGIN or IMC detected only by AFI-targeted biopsies) and value of AFI in selection of therapy (the proportion of patients for which detection of an HGIN or IMC lesion by AFI changed the treatment strategy based on white-light endoscopy or random biopsy analysis).

RESULTS: Of study participants, 211 were referred for surveillance and 160 were referred for early stage neoplasia; HGIN or IMC were diagnosed in 147 patients. In 211 patients undergoing surveillance, 39 had HGIN or IMC (23 detected by white-light endoscopy, 11 detected by random biopsies, 5 detected by AFI). So, the diagnostic value of AFI was 5 (2%) of 211. In 24 patients, HGIN or IMC was diagnosed using only AFI. In 33 patients, AFI detected additional HGINs or IMCs next to lesions detected by primary white-light endoscopy. Lesions detected by AFI were treated in 57 patients: 26 patients underwent radiofrequency ablation and showed full remission of neoplasia, whereas 31 underwent endoscopic resection and 6 were found to have IMC. The value of AFI in selection of therapy was 6 (2%) of 371.

CONCLUSIONS: Based on an analysis of data from clinical trials of patients with BE, detection of lesions by AFI has little effect on the diagnosis of early stage neoplasia or therapeutic decision making. AFI therefore has a limited role in routine surveillance or management of patients with BE.

Original languageEnglish
Pages (from-to)774-81
Number of pages8
JournalClinical Gastroenterology and Hepatology
Issue number5
Publication statusPublished - May 2014


  • Aged
  • Barrett Esophagus/complications
  • Carcinoma in Situ/diagnosis
  • Clinical Trials as Topic
  • Esophageal Neoplasms/diagnosis
  • Esophagoscopy
  • Female
  • Histocytochemistry
  • Humans
  • Male
  • Middle Aged
  • Optical Imaging/methods
  • Sensitivity and Specificity


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