TY - JOUR
T1 - Effects of 13-valent pneumococcal conjugate vaccination of adults on lower respiratory tract infections and antibiotic use in primary care
T2 - authors' response
AU - van Werkhoven, Cornelis H
AU - Bolkenbaas, Marieke
AU - Huijts, Susanne M
AU - Verheij, Theo J M
AU - Bonten, Marc J M
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - In response to Theilacker et al. we explain that we consider the point estimate as well as the confidence bounds in our interpretation of the study results and do not treat confidence intervals as a dichotomous signal. We refute that the proposed calculation of vaccine preventable disease incidence is more valuable than calculation of vaccine efficacy. Finally we remain at our conclusion that PCV13 vaccination in the elderly is unlikely to cause a relevant reduction in the incidence of CAP, LRTI, LRTI-related antibiotic use or total antibiotic use in primary care.
AB - In response to Theilacker et al. we explain that we consider the point estimate as well as the confidence bounds in our interpretation of the study results and do not treat confidence intervals as a dichotomous signal. We refute that the proposed calculation of vaccine preventable disease incidence is more valuable than calculation of vaccine efficacy. Finally we remain at our conclusion that PCV13 vaccination in the elderly is unlikely to cause a relevant reduction in the incidence of CAP, LRTI, LRTI-related antibiotic use or total antibiotic use in primary care.
UR - http://www.scopus.com/inward/record.url?scp=85100044427&partnerID=8YFLogxK
U2 - 10.1016/j.cmi.2020.12.033
DO - 10.1016/j.cmi.2020.12.033
M3 - Comment/Letter to the editor
C2 - 33421575
SN - 1198-743X
VL - 27
SP - 926
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 6
ER -