Effectiveness of personal protective equipment and oseltamivir prophylaxis during avian influenza A (H7N7) epidemic, the Netherlands, 2003

Dennis E te Beest; Michiel van Boven; Marian E H Bos; Arjan Stegeman; Marion P G Koopmans

doi:10.3201/eid1610.091412

Effectiveness of personal protective equipment and oseltamivir prophylaxis during avian influenza A (H7N7) epidemic, the Netherlands, 2003

Dennis E te Beest
, Michiel van Boven
, Marian E H Bos
, Arjan Stegeman
, Marion P G Koopmans

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We analyzed the effectiveness of personal protective equipment and oseltamivir use during the 2003 avian influenza A (H7N7) epidemic in the Netherlands by linking databases containing information about farm visits, human infections, and use of oseltamivir and personal protective equipment. Using a stringent case definition, based on self-reported conjunctivitis combined with a positive hemagglutination-inhibition assay, we found that prophylactic treatment with oseltamivir significantly reduced the risk for infection per farm visit from 0.145 (95% confidence interval [CI] 0.078-0.233) to 0.031 (95% CI 0.008-0.073). The protective effect was ≈79% (95% CI 40%-97%). These results are comparable with the reported effect of prophylactic treatment with oseltamivir on human seasonal influenza. No significant protective effect was found for use of respirators or safety glasses, possibly because of limitations of the data.

Original language	English
Pages (from-to)	1562-1568
Number of pages	7
Journal	Emerging infectious diseases
Volume	16
Issue number	10
DOIs	https://doi.org/10.3201/eid1610.091412
Publication status	Published - Oct 2010
Externally published	Yes

Keywords

Adolescent
Adult
Animal Husbandry
Animals
Antiviral Agents/therapeutic use
Chemoprevention
Disease Outbreaks/prevention & control
Eye Protective Devices/statistics & numerical data
Female
Humans
Influenza A Virus, H7N7 Subtype/pathogenicity
Influenza in Birds/epidemiology
Influenza, Human/epidemiology
Male
Middle Aged
Netherlands/epidemiology
Occupational Exposure
Oseltamivir/therapeutic use
Poultry/virology
Poultry Diseases/epidemiology
Protective Devices/statistics & numerical data
Respiratory Protective Devices/statistics & numerical data
Treatment Outcome
Young Adult

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10.3201/eid1610.091412

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title = "Effectiveness of personal protective equipment and oseltamivir prophylaxis during avian influenza A (H7N7) epidemic, the Netherlands, 2003",

abstract = "We analyzed the effectiveness of personal protective equipment and oseltamivir use during the 2003 avian influenza A (H7N7) epidemic in the Netherlands by linking databases containing information about farm visits, human infections, and use of oseltamivir and personal protective equipment. Using a stringent case definition, based on self-reported conjunctivitis combined with a positive hemagglutination-inhibition assay, we found that prophylactic treatment with oseltamivir significantly reduced the risk for infection per farm visit from 0.145 (95\% confidence interval [CI] 0.078-0.233) to 0.031 (95\% CI 0.008-0.073). The protective effect was ≈79\% (95\% CI 40\%-97\%). These results are comparable with the reported effect of prophylactic treatment with oseltamivir on human seasonal influenza. No significant protective effect was found for use of respirators or safety glasses, possibly because of limitations of the data.",

keywords = "Adolescent, Adult, Animal Husbandry, Animals, Antiviral Agents/therapeutic use, Chemoprevention, Disease Outbreaks/prevention \& control, Eye Protective Devices/statistics \& numerical data, Female, Humans, Influenza A Virus, H7N7 Subtype/pathogenicity, Influenza in Birds/epidemiology, Influenza, Human/epidemiology, Male, Middle Aged, Netherlands/epidemiology, Occupational Exposure, Oseltamivir/therapeutic use, Poultry/virology, Poultry Diseases/epidemiology, Protective Devices/statistics \& numerical data, Respiratory Protective Devices/statistics \& numerical data, Treatment Outcome, Young Adult",

author = "\{te Beest\}, \{Dennis E\} and \{van Boven\}, Michiel and Bos, \{Marian E H\} and Arjan Stegeman and Koopmans, \{Marion P G\}",

year = "2010",

month = oct,

doi = "10.3201/eid1610.091412",

language = "English",

volume = "16",

pages = "1562--1568",

journal = "Emerging infectious diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

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AU - te Beest, Dennis E

AU - van Boven, Michiel

AU - Bos, Marian E H

AU - Stegeman, Arjan

AU - Koopmans, Marion P G

PY - 2010/10

Y1 - 2010/10

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AB - We analyzed the effectiveness of personal protective equipment and oseltamivir use during the 2003 avian influenza A (H7N7) epidemic in the Netherlands by linking databases containing information about farm visits, human infections, and use of oseltamivir and personal protective equipment. Using a stringent case definition, based on self-reported conjunctivitis combined with a positive hemagglutination-inhibition assay, we found that prophylactic treatment with oseltamivir significantly reduced the risk for infection per farm visit from 0.145 (95% confidence interval [CI] 0.078-0.233) to 0.031 (95% CI 0.008-0.073). The protective effect was ≈79% (95% CI 40%-97%). These results are comparable with the reported effect of prophylactic treatment with oseltamivir on human seasonal influenza. No significant protective effect was found for use of respirators or safety glasses, possibly because of limitations of the data.

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KW - Eye Protective Devices/statistics & numerical data

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ER -

Effectiveness of personal protective equipment and oseltamivir prophylaxis during avian influenza A (H7N7) epidemic, the Netherlands, 2003

Abstract

Keywords

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