TY - JOUR
T1 - Effect of Vascular Risk Factors and Diseases on Mortality in Individuals with Dementia
T2 - A Systematic Review and Meta-Analysis
AU - Van De Vorst, Irene E.
AU - Koek, Huiberdina L.
AU - De Vries, Rehana
AU - Bots, Michiel L.
AU - Reitsma, Johannes B.
AU - Vaartjes, Ilonca
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Objectives To assess the effect of cardiovascular diseases and risk factors on mortality in individuals with dementia. Design Systematic review and meta-analysis. English- and Dutch-language studies in PubMed, EMBASE, and PsycINFO databases were searched in April 2014 with hand-searching of in-text citations and no publication limitations. Inclusion criteria were original studies reporting on cardiovascular risk factors or diseases and their relationship with survival in individuals with dementia. The Quality In Prognosis Studies tool was used to appraise all included articles. Setting Population-, hospital-, and nursing home-based. Participants Community-dwelling, hospitalized individuals and nursing home residents with dementia. Measurements A random-effects meta-analysis was performed to investigate the effect of several cardiovascular diseases and risk factors on overall mortality. Results Twelve studies with 235,865 participants were included. In pooled analyses, male sex (hazard ratio (HR) = 1.67, 95% confidence interval (CI) = 1.56-1.78), diabetes mellitus (DM) (HR = 1.49, 95% CI = 1.33-1.68), smoking (ever vs never) (HR = 1.37, 95% CI = 1.17-1.61), coronary heart disease (CHD) (HR = 1.21, 95% CI = 1.02-1.44) and congestive heart failure (CHF) (HR = 1.37, 95% CI = 1.18-1.59) were associated with mortality. Stroke, high blood pressure, being overweight, and hypercholesterolemia were not statistically significantly related to mortality. Conclusion Individuals with dementia and DM, smoking, CHD, and CHF have a greater risk of death than individuals with dementia without these risk factors or diseases.
AB - Objectives To assess the effect of cardiovascular diseases and risk factors on mortality in individuals with dementia. Design Systematic review and meta-analysis. English- and Dutch-language studies in PubMed, EMBASE, and PsycINFO databases were searched in April 2014 with hand-searching of in-text citations and no publication limitations. Inclusion criteria were original studies reporting on cardiovascular risk factors or diseases and their relationship with survival in individuals with dementia. The Quality In Prognosis Studies tool was used to appraise all included articles. Setting Population-, hospital-, and nursing home-based. Participants Community-dwelling, hospitalized individuals and nursing home residents with dementia. Measurements A random-effects meta-analysis was performed to investigate the effect of several cardiovascular diseases and risk factors on overall mortality. Results Twelve studies with 235,865 participants were included. In pooled analyses, male sex (hazard ratio (HR) = 1.67, 95% confidence interval (CI) = 1.56-1.78), diabetes mellitus (DM) (HR = 1.49, 95% CI = 1.33-1.68), smoking (ever vs never) (HR = 1.37, 95% CI = 1.17-1.61), coronary heart disease (CHD) (HR = 1.21, 95% CI = 1.02-1.44) and congestive heart failure (CHF) (HR = 1.37, 95% CI = 1.18-1.59) were associated with mortality. Stroke, high blood pressure, being overweight, and hypercholesterolemia were not statistically significantly related to mortality. Conclusion Individuals with dementia and DM, smoking, CHD, and CHF have a greater risk of death than individuals with dementia without these risk factors or diseases.
KW - cardiovascular disease
KW - dementia
KW - meta-analysis
KW - prognosis
KW - review
UR - http://www.scopus.com/inward/record.url?scp=84956624721&partnerID=8YFLogxK
U2 - 10.1111/jgs.13835
DO - 10.1111/jgs.13835
M3 - Article
C2 - 26782850
AN - SCOPUS:84956624721
SN - 0002-8614
VL - 64
SP - 37
EP - 46
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 1
ER -