Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography

M. Heron; J. C. Grutters; C. H.M. Van Moorsel; H. J.T. Ruven; K. M. Kazemier; A. M.E. Claessen; J. M.M. Van den Bosch

doi:10.1016/j.clim.2009.06.007

Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography

M. Heron, J. C. Grutters^*, C. H.M. Van Moorsel, H. J.T. Ruven, K. M. Kazemier, A. M.E. Claessen, J. M.M. Van den Bosch

^*Corresponding author for this work

Department of Pulmonary Diseases

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

The integrin α_Eβ₇ is believed to play a key role in retention of lymphocytes in mucosal tissues of gut, urogenital tract and lung. Five common single nucleotide polymorphisms spanning ITGAE, the gene encoding the α_E (CD103) unit, were genotyped in 556 sarcoidosis patients and 465 controls. The - 1088 A/G polymorphism was associated with sarcoidosis (P = 0.004). An increased risk of disease was found for homozygous carriers of the A allele vs. carriers of the G allele (P = 0.001, odds ratio = 1.63 [1.22-2.17]). Analysis of lymphocytes from bronchoalveolar lavage and in vitro functional tests showed higher percentages of CD103+CD4+ T cells for the sarcoidosis risk genotype. Radiographic staging at disease outcome revealed prevalence of - 1088 AA genotype in patients with fibrosis (P = 0.01). A higher proportion of CD103+CD4+ T cells and ITGAE - 1088 AA genotype might be associated with fibrosis formation in pulmonary sarcoidosis.

Original language	English
Pages (from-to)	117-125
Number of pages	9
Journal	Clinical Immunology
Volume	133
Issue number	1
DOIs	https://doi.org/10.1016/j.clim.2009.06.007
Publication status	Published - Oct 2009

Keywords

CD103
Epithelium
Fibrosis
ITGAE
Sarcoidosis
Single nuclear polymorphism

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10.1016/j.clim.2009.06.007

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title = "Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography",

abstract = "The integrin αEβ7 is believed to play a key role in retention of lymphocytes in mucosal tissues of gut, urogenital tract and lung. Five common single nucleotide polymorphisms spanning ITGAE, the gene encoding the αE (CD103) unit, were genotyped in 556 sarcoidosis patients and 465 controls. The - 1088 A/G polymorphism was associated with sarcoidosis (P = 0.004). An increased risk of disease was found for homozygous carriers of the A allele vs. carriers of the G allele (P = 0.001, odds ratio = 1.63 [1.22-2.17]). Analysis of lymphocytes from bronchoalveolar lavage and in vitro functional tests showed higher percentages of CD103+CD4+ T cells for the sarcoidosis risk genotype. Radiographic staging at disease outcome revealed prevalence of - 1088 AA genotype in patients with fibrosis (P = 0.01). A higher proportion of CD103+CD4+ T cells and ITGAE - 1088 AA genotype might be associated with fibrosis formation in pulmonary sarcoidosis.",

keywords = "CD103, Epithelium, Fibrosis, ITGAE, Sarcoidosis, Single nuclear polymorphism",

author = "M. Heron and Grutters, {J. C.} and {Van Moorsel}, {C. H.M.} and Ruven, {H. J.T.} and Kazemier, {K. M.} and Claessen, {A. M.E.} and {Van den Bosch}, {J. M.M.}",

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AU - Heron, M.

AU - Grutters, J. C.

AU - Van Moorsel, C. H.M.

AU - Ruven, H. J.T.

AU - Kazemier, K. M.

AU - Claessen, A. M.E.

AU - Van den Bosch, J. M.M.

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N2 - The integrin αEβ7 is believed to play a key role in retention of lymphocytes in mucosal tissues of gut, urogenital tract and lung. Five common single nucleotide polymorphisms spanning ITGAE, the gene encoding the αE (CD103) unit, were genotyped in 556 sarcoidosis patients and 465 controls. The - 1088 A/G polymorphism was associated with sarcoidosis (P = 0.004). An increased risk of disease was found for homozygous carriers of the A allele vs. carriers of the G allele (P = 0.001, odds ratio = 1.63 [1.22-2.17]). Analysis of lymphocytes from bronchoalveolar lavage and in vitro functional tests showed higher percentages of CD103+CD4+ T cells for the sarcoidosis risk genotype. Radiographic staging at disease outcome revealed prevalence of - 1088 AA genotype in patients with fibrosis (P = 0.01). A higher proportion of CD103+CD4+ T cells and ITGAE - 1088 AA genotype might be associated with fibrosis formation in pulmonary sarcoidosis.

AB - The integrin αEβ7 is believed to play a key role in retention of lymphocytes in mucosal tissues of gut, urogenital tract and lung. Five common single nucleotide polymorphisms spanning ITGAE, the gene encoding the αE (CD103) unit, were genotyped in 556 sarcoidosis patients and 465 controls. The - 1088 A/G polymorphism was associated with sarcoidosis (P = 0.004). An increased risk of disease was found for homozygous carriers of the A allele vs. carriers of the G allele (P = 0.001, odds ratio = 1.63 [1.22-2.17]). Analysis of lymphocytes from bronchoalveolar lavage and in vitro functional tests showed higher percentages of CD103+CD4+ T cells for the sarcoidosis risk genotype. Radiographic staging at disease outcome revealed prevalence of - 1088 AA genotype in patients with fibrosis (P = 0.01). A higher proportion of CD103+CD4+ T cells and ITGAE - 1088 AA genotype might be associated with fibrosis formation in pulmonary sarcoidosis.

KW - CD103

KW - Epithelium

KW - Fibrosis

KW - ITGAE

KW - Sarcoidosis

KW - Single nuclear polymorphism

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Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography

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