Effect of scaffold architecture on composition of tissue engineered cartilage

J. Malda*, T. Woodfield, F. Van Der Vloodt, C. Wilson, D. E. Martens, J. Tramper, C. A. Van Blitterswijk, J. Riesle

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

The effect of scaffold architecture on composition of tissue engineered cartilage was discussed. Two processing techniques, compression-molding / particulate-leaching (CM) and three dimensional fiber deposition (3DF), were used to develop porous scaffolds from biodegradable poly(ethylene glycol)-terephthalate/poly(butylene terephthalate (PEGT/PBT) co-polymers with varying pore architectures. Three-dimensional micro-computed tomography (μCT) was used to characterize scaffold architectures and scaffolds were seeded with articular chondrocytes to evaluate tissue formation. Highly interconnected 3DF scaffolds create an environment in vivo that enhances deposition of matrix with resemblance to native cartilage tissue.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
Publication statusPublished - 1 Dec 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 17 May 200421 May 2004

Conference

ConferenceTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period17/05/0421/05/04

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