Effect of Manganese in test media on in vitro susceptibility of Enterobacteriaceae and Acinetobacter baumannii to tigecycline

J. Veenemans; J. W. Mouton; J. A.J.W. Kluytmans; R. Donnely; C. Verhulst; P. H.J. Van Keulen

doi:10.1128/JCM.01485-12

Effect of Manganese in test media on in vitro susceptibility of Enterobacteriaceae and Acinetobacter baumannii to tigecycline

J. Veenemans, J. W. Mouton, J. A.J.W. Kluytmans^*, R. Donnely, C. Verhulst, P. H.J. Van Keulen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

We assessed the effect of increasing manganese concentrations in test media (0.001 to 1,024 mg/liter) on MICs of tigecycline. For both broth microdilution (BMD) and Etests, this effect was negligible for physiological concentrations, but MICs increased when concentrations exceeded 8 mg/liter. Susceptibility testing should be performed on media with standardized low manganese content.

Original language	English
Pages (from-to)	3077-3079
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	50
Issue number	9
DOIs	https://doi.org/10.1128/JCM.01485-12
Publication status	Published - Sept 2012
Externally published	Yes

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title = "Effect of Manganese in test media on in vitro susceptibility of Enterobacteriaceae and Acinetobacter baumannii to tigecycline",

abstract = "We assessed the effect of increasing manganese concentrations in test media (0.001 to 1,024 mg/liter) on MICs of tigecycline. For both broth microdilution (BMD) and Etests, this effect was negligible for physiological concentrations, but MICs increased when concentrations exceeded 8 mg/liter. Susceptibility testing should be performed on media with standardized low manganese content.",

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AU - Veenemans, J.

AU - Mouton, J. W.

AU - Kluytmans, J. A.J.W.

AU - Donnely, R.

AU - Verhulst, C.

AU - Van Keulen, P. H.J.

PY - 2012/9

Y1 - 2012/9

N2 - We assessed the effect of increasing manganese concentrations in test media (0.001 to 1,024 mg/liter) on MICs of tigecycline. For both broth microdilution (BMD) and Etests, this effect was negligible for physiological concentrations, but MICs increased when concentrations exceeded 8 mg/liter. Susceptibility testing should be performed on media with standardized low manganese content.

AB - We assessed the effect of increasing manganese concentrations in test media (0.001 to 1,024 mg/liter) on MICs of tigecycline. For both broth microdilution (BMD) and Etests, this effect was negligible for physiological concentrations, but MICs increased when concentrations exceeded 8 mg/liter. Susceptibility testing should be performed on media with standardized low manganese content.

UR - https://www.scopus.com/pages/publications/84865194724

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DO - 10.1128/JCM.01485-12

M3 - Article

C2 - 22718943

AN - SCOPUS:84865194724

SN - 0095-1137

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JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

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ER -

Effect of Manganese in test media on in vitro susceptibility of Enterobacteriaceae and Acinetobacter baumannii to tigecycline

Abstract

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