Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome

Arja Suzanne Vink; Sally-Ann B Clur; Arthur A M Wilde; Nico A Blom

doi:10.1016/j.tcm.2017.07.012

Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome

Arja Suzanne Vink^*
, Sally-Ann B Clur
, Arthur A M Wilde
, Nico A Blom

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Age- and gender-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of sex hormones on the QTc-interval are not known, testosterone appears to shorten the QTc-interval. In females, however, there is a more complex interaction between progesterone and estrogen. In patients with an impaired repolarization, such as long-QT syndrome (LQTS), the effect of these sex hormones on the QTc-interval is more pronounced with a differing sensitivity between the LQTS genotypes.

Original language	English
Pages (from-to)	64-75
Number of pages	12
Journal	Trends in Cardiovascular Medicine
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.tcm.2017.07.012
Publication status	Published - Jan 2018
Externally published	Yes

Keywords

Action Potentials
Age Factors
Electrocardiography
Estrogens/blood
Female
Health Status Disparities
Heart Conduction System/physiopathology
Heart Rate
Humans
Long QT Syndrome/blood
Male
Menstrual Cycle
Predictive Value of Tests
Progesterone/blood
Prognosis
Risk Factors
Sex Factors
Testosterone/blood

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10.1016/j.tcm.2017.07.012

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title = "Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome",

abstract = "Age- and gender-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of sex hormones on the QTc-interval are not known, testosterone appears to shorten the QTc-interval. In females, however, there is a more complex interaction between progesterone and estrogen. In patients with an impaired repolarization, such as long-QT syndrome (LQTS), the effect of these sex hormones on the QTc-interval is more pronounced with a differing sensitivity between the LQTS genotypes.",

keywords = "Action Potentials, Age Factors, Electrocardiography, Estrogens/blood, Female, Health Status Disparities, Heart Conduction System/physiopathology, Heart Rate, Humans, Long QT Syndrome/blood, Male, Menstrual Cycle, Predictive Value of Tests, Progesterone/blood, Prognosis, Risk Factors, Sex Factors, Testosterone/blood",

author = "Vink, \{Arja Suzanne\} and Clur, \{Sally-Ann B\} and Wilde, \{Arthur A M\} and Blom, \{Nico A\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = jan,

doi = "10.1016/j.tcm.2017.07.012",

language = "English",

volume = "28",

pages = "64--75",

journal = "Trends in Cardiovascular Medicine",

issn = "1050-1738",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome

AU - Vink, Arja Suzanne

AU - Clur, Sally-Ann B

AU - Wilde, Arthur A M

AU - Blom, Nico A

PY - 2018/1

Y1 - 2018/1

N2 - Age- and gender-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of sex hormones on the QTc-interval are not known, testosterone appears to shorten the QTc-interval. In females, however, there is a more complex interaction between progesterone and estrogen. In patients with an impaired repolarization, such as long-QT syndrome (LQTS), the effect of these sex hormones on the QTc-interval is more pronounced with a differing sensitivity between the LQTS genotypes.

AB - Age- and gender-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of sex hormones on the QTc-interval are not known, testosterone appears to shorten the QTc-interval. In females, however, there is a more complex interaction between progesterone and estrogen. In patients with an impaired repolarization, such as long-QT syndrome (LQTS), the effect of these sex hormones on the QTc-interval is more pronounced with a differing sensitivity between the LQTS genotypes.

KW - Action Potentials

KW - Age Factors

KW - Electrocardiography

KW - Estrogens/blood

KW - Female

KW - Health Status Disparities

KW - Heart Conduction System/physiopathology

KW - Heart Rate

KW - Humans

KW - Long QT Syndrome/blood

KW - Male

KW - Menstrual Cycle

KW - Predictive Value of Tests

KW - Progesterone/blood

KW - Prognosis

KW - Risk Factors

KW - Sex Factors

KW - Testosterone/blood

U2 - 10.1016/j.tcm.2017.07.012

DO - 10.1016/j.tcm.2017.07.012

M3 - Review article

C2 - 28869094

SN - 1050-1738

VL - 28

SP - 64

EP - 75

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 1

ER -

Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome

Abstract

Keywords

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