TY - JOUR
T1 - EEG-based neurophysiological indicators of hallucinations in Alzheimer's disease
T2 - Comparison with dementia with Lewy bodies
AU - Dauwan, Meenakshi
AU - Linszen, Mascha M.J.
AU - Lemstra, Afina W.
AU - Scheltens, Philip
AU - Stam, Cornelis J.
AU - Sommer, Iris E.
N1 - Funding Information:
This study was partly supported by ZONMW TOP grant 40-00812-98-13009.
Funding Information:
This study was partly supported by ZONMW TOP grant 40-00812-98-13009.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - We studied neurophysiological indicators of hallucinations in Alzheimer's disease patients with hallucinations (ADhall+), and compared them with nonhallucinating AD (ADhall−) and dementia with Lewy bodies (DLBhall+) patients. Thirty-six matched ADhall+ and 108 ADhall− and 29 DLBhall+ patients were selected from the Amsterdam Dementia Cohort. Electroencephalography (EEG) spectral and functional connectivity (FC) analyses (phase lag index) were performed. Quantitative and visual EEG measures were combined in a random forest algorithm to determine which EEG-based variable(s) play a role in hallucinations. ADhall+ patients showed lower peak frequency (7.26 vs. 7.94 Hz, p < 0.01), α2-and β-power, and α2-FC but higher δ-power compared to ADhall−. ADhall+ showed lower δ-power, higher β-power, and α1-FC than DLBhall+ but did not differ in peak frequency (7.26 vs. 6.95 Hz), θ- or α-power. ADhall+ patients could be differentiated from ADhall− and DLBhall+ with a weighted accuracy of 71% with α1-power and 100% with β-FC, the 2 most differentiating features. In sum, EEG slowing and decrease in α1-and β-band activity form potential neurophysiological indicators of underlying cholinergic deficiency in ADhall+ and DLBhall+.
AB - We studied neurophysiological indicators of hallucinations in Alzheimer's disease patients with hallucinations (ADhall+), and compared them with nonhallucinating AD (ADhall−) and dementia with Lewy bodies (DLBhall+) patients. Thirty-six matched ADhall+ and 108 ADhall− and 29 DLBhall+ patients were selected from the Amsterdam Dementia Cohort. Electroencephalography (EEG) spectral and functional connectivity (FC) analyses (phase lag index) were performed. Quantitative and visual EEG measures were combined in a random forest algorithm to determine which EEG-based variable(s) play a role in hallucinations. ADhall+ patients showed lower peak frequency (7.26 vs. 7.94 Hz, p < 0.01), α2-and β-power, and α2-FC but higher δ-power compared to ADhall−. ADhall+ showed lower δ-power, higher β-power, and α1-FC than DLBhall+ but did not differ in peak frequency (7.26 vs. 6.95 Hz), θ- or α-power. ADhall+ patients could be differentiated from ADhall− and DLBhall+ with a weighted accuracy of 71% with α1-power and 100% with β-FC, the 2 most differentiating features. In sum, EEG slowing and decrease in α1-and β-band activity form potential neurophysiological indicators of underlying cholinergic deficiency in ADhall+ and DLBhall+.
KW - Alzheimer's disease
KW - Dementia with Lewy bodies
KW - EEG
KW - Hallucinations
KW - Random forest
UR - http://www.scopus.com/inward/record.url?scp=85045096549&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2018.03.013
DO - 10.1016/j.neurobiolaging.2018.03.013
M3 - Article
C2 - 29653315
AN - SCOPUS:85045096549
SN - 0197-4580
VL - 67
SP - 75
EP - 83
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -