Editorial Expression of Concern: The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes (Nature, 10.1038/nature02171)

Lakshmanan Ganesh; Ezra Burstein; Anuradha Guha-Niyogi; Mark K. Louder; John R. Mascola; Leo W.J. Klomp; Cisca Wijmenga; Colin S. Duckett; Gary J. Nabel

doi:10.1038/s41586-026-10308-x

Editorial Expression of Concern: The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes (Nature, 10.1038/nature02171)

Lakshmanan Ganesh
, Ezra Burstein
, Anuradha Guha-Niyogi
, Mark K. Louder
, John R. Mascola
, Leo W.J. Klomp
, Cisca Wijmenga
, Colin S. Duckett
, Gary J. Nabel^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

The Editors are issuing this expression of concern to alert readers that in Fig. 3b the control panels were duplicated. These control panels were included to show that the Murr1 siRNA was active. In Fig. 3c and d separate panels independently confirm the specificity of the knockdown with respect to two separate reference genes, Skp1 and Actin. The raw data is no longer available for verification due to the age of the article. Ezra Burstein, Anuradha Guha-Niyogi, John R. Mascola, Leo W. J. Klomp, Cisca Wijmenga, Colin S. Duckett & Gary J. Nabel agree to this expression of concern. Lakshmanan Ganesh and Mark K. Louder are deceased.

Original language	English
Pages (from-to)	E15-E15
Journal	Nature
Volume	651
Issue number	8106
Early online date	2026
DOIs	https://doi.org/10.1038/s41586-026-10308-x
Publication status	Published - 19 Mar 2026
Externally published	Yes

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s41586-026-10308-xFinal published version, 510 KBLicence: Taverne

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title = "Editorial Expression of Concern: The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes (Nature, 10.1038/nature02171)",

abstract = "The Editors are issuing this expression of concern to alert readers that in Fig. 3b the control panels were duplicated. These control panels were included to show that the Murr1 siRNA was active. In Fig. 3c and d separate panels independently confirm the specificity of the knockdown with respect to two separate reference genes, Skp1 and Actin. The raw data is no longer available for verification due to the age of the article. Ezra Burstein, Anuradha Guha-Niyogi, John R. Mascola, Leo W. J. Klomp, Cisca Wijmenga, Colin S. Duckett \& Gary J. Nabel agree to this expression of concern. Lakshmanan Ganesh and Mark K. Louder are deceased.",

author = "Lakshmanan Ganesh and Ezra Burstein and Anuradha Guha-Niyogi and Louder, \{Mark K.\} and Mascola, \{John R.\} and Klomp, \{Leo W.J.\} and Cisca Wijmenga and Duckett, \{Colin S.\} and Nabel, \{Gary J.\}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2026.",

year = "2026",

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doi = "10.1038/s41586-026-10308-x",

language = "English",

volume = "651",

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T2 - The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes (Nature, 10.1038/nature02171)

AU - Ganesh, Lakshmanan

AU - Burstein, Ezra

AU - Guha-Niyogi, Anuradha

AU - Louder, Mark K.

AU - Mascola, John R.

AU - Klomp, Leo W.J.

AU - Wijmenga, Cisca

AU - Duckett, Colin S.

AU - Nabel, Gary J.

PY - 2026/3/19

Y1 - 2026/3/19

N2 - The Editors are issuing this expression of concern to alert readers that in Fig. 3b the control panels were duplicated. These control panels were included to show that the Murr1 siRNA was active. In Fig. 3c and d separate panels independently confirm the specificity of the knockdown with respect to two separate reference genes, Skp1 and Actin. The raw data is no longer available for verification due to the age of the article. Ezra Burstein, Anuradha Guha-Niyogi, John R. Mascola, Leo W. J. Klomp, Cisca Wijmenga, Colin S. Duckett & Gary J. Nabel agree to this expression of concern. Lakshmanan Ganesh and Mark K. Louder are deceased.

AB - The Editors are issuing this expression of concern to alert readers that in Fig. 3b the control panels were duplicated. These control panels were included to show that the Murr1 siRNA was active. In Fig. 3c and d separate panels independently confirm the specificity of the knockdown with respect to two separate reference genes, Skp1 and Actin. The raw data is no longer available for verification due to the age of the article. Ezra Burstein, Anuradha Guha-Niyogi, John R. Mascola, Leo W. J. Klomp, Cisca Wijmenga, Colin S. Duckett & Gary J. Nabel agree to this expression of concern. Lakshmanan Ganesh and Mark K. Louder are deceased.

UR - https://www.scopus.com/pages/publications/105031490028

U2 - 10.1038/s41586-026-10308-x

DO - 10.1038/s41586-026-10308-x

M3 - Comment/Letter to the editor

AN - SCOPUS:105031490028

SN - 0028-0836

VL - 651

SP - E15-E15

JO - Nature

JF - Nature

IS - 8106

ER -

Editorial Expression of Concern: The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes (Nature, 10.1038/nature02171)

Abstract

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