Early outcome after off-pump versus on-pump coronary bypass surgery: results from a randomized study

D. van Dijk, A.P. Nierich, E.W.L. Jansen, H.M. Nathoe, W.J.L. Suyker, J.C. Diephuis, W.J. van Boven, C. Borst, E. Buskens, D.E. Grobbee, E.O. Robles de Medina, P.P.T. de Jaegere

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: The use of cardiopulmonary bypass during coronary artery bypass surgery (CABG) has been associated with substantial morbidity. The recent introduction of cardiac stabilizers facilitates CABG without cardiopulmonary bypass (off-pump CABG), but it is unknown whether cardiac outcome after off-pump surgery is similar to that for the on-pump procedure.

METHODS AND RESULTS: In a multicenter trial, 281 patients (mean age 61 years, SD 9 years) were randomly assigned to off-pump or on-pump CABG. In-hospital results and cardiac outcome and quality of life after 1 month are presented. Cardiac outcome was defined as survival free of stroke, myocardial infarction, and coronary reintervention. The mean numbers of distal anastomoses per patient were 2.4 (SD 1.0) and 2.6 (SD 1.1) in the off-pump and on-pump groups, respectively. Completeness of revascularization was similar in both groups. Blood products were needed during 3% of the off-pump procedures and 13% of the on-pump procedures (P<0.01). Release of creatine kinase muscle-brain isoenzyme was 41% less in the off-pump group (P<0.01). Otherwise, no differences in complications were found postoperatively. Off-pump patients were discharged 1 day earlier. At 1 month, operative mortality was zero in both groups, and quality of life had improved similarly. In both groups, 4% of the patients had recurrent angina. The proportions of patients surviving free of cardiovascular events were 93.0% in the off-pump group and 94.2% in the on-pump group (P=0.66).

CONCLUSIONS: In selected patients, off-pump CABG is safe and yields a short-term cardiac outcome comparable to that of on-pump CABG.

Original languageEnglish
Pages (from-to)1761-1766
Number of pages6
JournalCirculation
Volume104
Issue number15
Publication statusPublished - 2001

Keywords

  • Cardiopulmonary Bypass
  • Coronary Artery Bypass
  • Coronary Artery Disease
  • Disease-Free Survival
  • Extracorporeal Circulation
  • Female
  • Follow-Up Studies
  • Hospital Costs
  • Humans
  • Intraoperative Period
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Postoperative Period
  • Quality of Life
  • Reoperation
  • Stroke
  • Treatment Outcome

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