TY - JOUR
T1 - Early-Onset Sepsis as an Early Predictor for Retinopathy of Prematurity
T2 - A Meta-analysis
AU - El Emrani, Salma
AU - Van Der Meeren, Lotte E.
AU - Jansen, Esther J.S.
AU - Goeman, Jelle J.
AU - Termote, Jacqueline U.M.
AU - Lopriore, Enrico
AU - Schalij-Delfos, Nicoline E.
N1 - Publisher Copyright:
© 2024 Thieme Medical Publishers, Inc.. All rights reserved.
PY - 2025/2
Y1 - 2025/2
N2 - Objective Neonatal sepsis has been established as a risk factor for retinopathy of prematurity (ROP) but previous meta-analyses have predominately focused on late-onset sepsis (LOS). This meta-analysis aims to explore the association between early-onset sepsis (EOS) and the risk of ROP. Study Design Observational studies reporting (unadjusted) data on proven EOS in neonates with ROP were included. PubMed, Embase, and Cochrane Library were searched. Proven EOS was defined as a positive blood or cerebrospinal fluid culture. Effect sizes were calculated by using logistic random-effects models and meta-regression analyses. Primary outcomes were any stage ROP and severe ROP (≥stage 3, type I, aggressive [posterior] ROP, plus disease or requiring treatment). Potential confounders explored were gestational age at birth, birth weight, small for gestational age, maternal steroid use, necrotizing enterocolitis, LOS, and mechanical ventilation duration. Results Seventeen studies reporting the incidence of proven EOS in neonates with ROP were included. Proven EOS showed no significant association with any stage ROP (odds ratio [OR] = 1.90; 95% confidence interval [CI]: 0.96-3.79, p = 0.067) but heterogeneity between studies was significantly high. Neonates with proven EOS had an increased risk for severe ROP (OR = 2.21; 95% CI: 1.68-2.90), and no significant confounders influencing this effect size were found in the meta-regression analysis. Conclusion Neonates with proven EOS are at increased risk of severe ROP. Neonatologists need to be aware that EOS is an early predictor of ROP and should adapt their policy and treatment decisions where possible to reduce ROP. Key Points This meta-analysis reveals a 2.2-fold increased risk of severe ROP in neonates with proven EOS. Future studies should distinguish between EOS and LOS when investigating risk factors of ROP. Treatment decisions should be adapted where possible in neonates with EOS before ROP screening begins.
AB - Objective Neonatal sepsis has been established as a risk factor for retinopathy of prematurity (ROP) but previous meta-analyses have predominately focused on late-onset sepsis (LOS). This meta-analysis aims to explore the association between early-onset sepsis (EOS) and the risk of ROP. Study Design Observational studies reporting (unadjusted) data on proven EOS in neonates with ROP were included. PubMed, Embase, and Cochrane Library were searched. Proven EOS was defined as a positive blood or cerebrospinal fluid culture. Effect sizes were calculated by using logistic random-effects models and meta-regression analyses. Primary outcomes were any stage ROP and severe ROP (≥stage 3, type I, aggressive [posterior] ROP, plus disease or requiring treatment). Potential confounders explored were gestational age at birth, birth weight, small for gestational age, maternal steroid use, necrotizing enterocolitis, LOS, and mechanical ventilation duration. Results Seventeen studies reporting the incidence of proven EOS in neonates with ROP were included. Proven EOS showed no significant association with any stage ROP (odds ratio [OR] = 1.90; 95% confidence interval [CI]: 0.96-3.79, p = 0.067) but heterogeneity between studies was significantly high. Neonates with proven EOS had an increased risk for severe ROP (OR = 2.21; 95% CI: 1.68-2.90), and no significant confounders influencing this effect size were found in the meta-regression analysis. Conclusion Neonates with proven EOS are at increased risk of severe ROP. Neonatologists need to be aware that EOS is an early predictor of ROP and should adapt their policy and treatment decisions where possible to reduce ROP. Key Points This meta-analysis reveals a 2.2-fold increased risk of severe ROP in neonates with proven EOS. Future studies should distinguish between EOS and LOS when investigating risk factors of ROP. Treatment decisions should be adapted where possible in neonates with EOS before ROP screening begins.
KW - early-onset sepsis
KW - meta-analysis
KW - prematurity
KW - retinopathy of prematurity
UR - http://www.scopus.com/inward/record.url?scp=85201709825&partnerID=8YFLogxK
U2 - 10.1055/a-2369-6690
DO - 10.1055/a-2369-6690
M3 - Article
C2 - 39029916
AN - SCOPUS:85201709825
SN - 0735-1631
VL - 42
SP - 387
EP - 394
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 3
ER -