TY - JOUR
T1 - Early diagnosis of primary Sjögren's syndrome
T2 - EULAR-SS task force clinical recommendations
AU - Brito-Zerón, Pilar
AU - Theander, Elke
AU - Baldini, Chiara
AU - Seror, Raphaèle
AU - Retamozo, Soledad
AU - Quartuccio, Luca
AU - Bootsma, Hendrika
AU - Bowman, Simon J
AU - Dörner, Thomas
AU - Gottenberg, Jacques-Eric
AU - Mariette, Xavier
AU - Bombardieri, Stefano
AU - de Vita, Salvatore
AU - Mandl, Thomas
AU - Ng, Wan-Fai
AU - Kruize, Aike A
AU - Tzioufas, Athanasios
AU - Vitali, Claudio
AU - Buyon, Jill
AU - Izmirly, Peter
AU - Fox, Robert
AU - Ramos-Casals, Manuel
PY - 2016
Y1 - 2016
N2 - Sjögren's syndrome (SjS) is a systemic autoimmune disease that mainly affects the exocrine glands, leading to generalized mucosal dryness. However, primary SjS may initially present with non-sicca (systemic) manifestations. When these features appear before the onset of an overt sicca syndrome, we may talk of an underlying 'occult' SjS. The European League Against Rheumatism (EULAR) has promoted and supported an international collaborative study group (EULAR-SS Task Force) aimed at developing consensual recommendations to provide a homogeneous approach to the patient with primary SjS presenting with systemic involvement. This review summarizes the key factors that should be taken into account in the diagnostic approach in a patient with suspected SjS according to the main clinical patterns of presentation, and is especially focused on organ-specific systemic disease presentations, including a consensus set of recommendations in order to reach an early diagnosis. Close collaboration with the different specialties involved through a comprehensive multidisciplinary approach is essential in SjS patients presenting with systemic involvements.
AB - Sjögren's syndrome (SjS) is a systemic autoimmune disease that mainly affects the exocrine glands, leading to generalized mucosal dryness. However, primary SjS may initially present with non-sicca (systemic) manifestations. When these features appear before the onset of an overt sicca syndrome, we may talk of an underlying 'occult' SjS. The European League Against Rheumatism (EULAR) has promoted and supported an international collaborative study group (EULAR-SS Task Force) aimed at developing consensual recommendations to provide a homogeneous approach to the patient with primary SjS presenting with systemic involvement. This review summarizes the key factors that should be taken into account in the diagnostic approach in a patient with suspected SjS according to the main clinical patterns of presentation, and is especially focused on organ-specific systemic disease presentations, including a consensus set of recommendations in order to reach an early diagnosis. Close collaboration with the different specialties involved through a comprehensive multidisciplinary approach is essential in SjS patients presenting with systemic involvements.
KW - Sjögren syndrome, anti-Ro/SS-A antibodies, systemic activity, ESSDAI, classification criteria, focal lymphocytic sialadenitis, early diagnosis
U2 - 10.1586/1744666X.2016.1109449
DO - 10.1586/1744666X.2016.1109449
M3 - Article
C2 - 26691952
SN - 1744-666X
VL - 12
SP - 137
EP - 156
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
IS - 2
ER -