Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs

M.I.F.J. Oerlemans; A. Mosterd; M.S. Dekker; E.A. de Vrey; A. van Mil; G. Pasterkamp; P.A.F.M. Doevendans; A.W. Hoes; J.P.G. Sluijter

doi:10.1002/emmm.201201749

Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs

M.I.F.J. Oerlemans, A. Mosterd, M.S. Dekker, E.A. de Vrey, A. van Mil, G. Pasterkamp, P.A.F.M. Doevendans, A.W. Hoes, J.P.G. Sluijter

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Previous studies investigating the role of circulating microRNAs in acute coronary syndrome (ACS) were based on small patient numbers, performed no comparison with established markers of cardiac injury and did not have appropriate controls. We determined the potential diagnostic value of circulating microRNAs as novel early biomarkers in 332 suspected ACS patients on presentation to the emergency department (ED) in a prospective single-centre study including cardiac miRNAs (miR-1, -208a and -499), miR-21 and miR-146a. Levels of all miRs studied were significantly increased in 106 patients diagnosed with ACS, even in patients with initially negative high-sensitive (hs) troponin or symptom onset

Original language	English
Pages (from-to)	1176-1185
Number of pages	10
Journal	Embo Molecular Medicine
Volume	4
Issue number	11
DOIs	https://doi.org/10.1002/emmm.201201749
Publication status	Published - Nov 2012

Keywords

acute coronary syndrome
circulating microRNA
miR-1
miR-21
miR-499
ACUTE MYOCARDIAL-INFARCTION
CARDIOVASCULAR-DISEASE
PLASMA MICRORNA
HEART-FAILURE
BIOMARKERS
SERUM
TROPONIN
REVEALS
MARKERS
CANCER

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10.1002/emmm.201201749

http://www.ncbi.nlm.nih.gov/pubmed/23023917;http://onlinelibrary.wiley.com/doi/10.1002/emmm.201201749/abstract;jsessionid=DDCB864DE05699D3DDCF80383289D5DA.d01t03

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Oerlemans, M. I. F. J., Mosterd, A., Dekker, M. S., de Vrey, E. A., van Mil, A., Pasterkamp, G., Doevendans, P. A. F. M., Hoes, A. W., & Sluijter, J. P. G. (2012). Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs. Embo Molecular Medicine, 4(11), 1176-1185. https://doi.org/10.1002/emmm.201201749

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title = "Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs",

abstract = "Previous studies investigating the role of circulating microRNAs in acute coronary syndrome (ACS) were based on small patient numbers, performed no comparison with established markers of cardiac injury and did not have appropriate controls. We determined the potential diagnostic value of circulating microRNAs as novel early biomarkers in 332 suspected ACS patients on presentation to the emergency department (ED) in a prospective single-centre study including cardiac miRNAs (miR-1, -208a and -499), miR-21 and miR-146a. Levels of all miRs studied were significantly increased in 106 patients diagnosed with ACS, even in patients with initially negative high-sensitive (hs) troponin or symptom onset",

keywords = "acute coronary syndrome, circulating microRNA, miR-1, miR-21, miR-499, ACUTE MYOCARDIAL-INFARCTION, CARDIOVASCULAR-DISEASE, PLASMA MICRORNA, HEART-FAILURE, BIOMARKERS, SERUM, TROPONIN, REVEALS, MARKERS, CANCER",

author = "M.I.F.J. Oerlemans and A. Mosterd and M.S. Dekker and {de Vrey}, E.A. and {van Mil}, A. and G. Pasterkamp and P.A.F.M. Doevendans and A.W. Hoes and J.P.G. Sluijter",

year = "2012",

month = nov,

doi = "10.1002/emmm.201201749",

language = "English",

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T2 - the potential diagnostic value of circulating microRNAs

AU - Oerlemans, M.I.F.J.

AU - Mosterd, A.

AU - Dekker, M.S.

AU - de Vrey, E.A.

AU - van Mil, A.

AU - Pasterkamp, G.

AU - Doevendans, P.A.F.M.

AU - Hoes, A.W.

AU - Sluijter, J.P.G.

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AB - Previous studies investigating the role of circulating microRNAs in acute coronary syndrome (ACS) were based on small patient numbers, performed no comparison with established markers of cardiac injury and did not have appropriate controls. We determined the potential diagnostic value of circulating microRNAs as novel early biomarkers in 332 suspected ACS patients on presentation to the emergency department (ED) in a prospective single-centre study including cardiac miRNAs (miR-1, -208a and -499), miR-21 and miR-146a. Levels of all miRs studied were significantly increased in 106 patients diagnosed with ACS, even in patients with initially negative high-sensitive (hs) troponin or symptom onset

KW - acute coronary syndrome

KW - circulating microRNA

KW - miR-1

KW - miR-21

KW - miR-499

KW - ACUTE MYOCARDIAL-INFARCTION

KW - CARDIOVASCULAR-DISEASE

KW - PLASMA MICRORNA

KW - HEART-FAILURE

KW - BIOMARKERS

KW - SERUM

KW - TROPONIN

KW - REVEALS

KW - MARKERS

KW - CANCER

U2 - 10.1002/emmm.201201749

DO - 10.1002/emmm.201201749

M3 - Article

SN - 1757-4676

VL - 4

SP - 1176

EP - 1185

JO - Embo Molecular Medicine

JF - Embo Molecular Medicine

IS - 11

ER -

Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs

Abstract

Keywords

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