Duration of untreated illness in schizophrenia is not associated with 5-year brain volume change

G. Boonstra; W. Cahn; H.G. Schnack; H.E. Hulshoff Pol; T.C. Minderhoud; R.S. Kahn; N.E.M. van Haren

doi:10.1016/j.schres.2011.07.018

Duration of untreated illness in schizophrenia is not associated with 5-year brain volume change

G. Boonstra, W. Cahn, H.G. Schnack, H.E. Hulshoff Pol, T.C. Minderhoud, R.S. Kahn, N.E.M. van Haren

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: Evidence for an association between duration of untreated illness (DUI) with clinical and functional outcome or brain volume (change) in schizophrenia patients is inconclusive. We aimed to investigate the relationship between DUI, outcome and brain volume at illness onset or brain volume change during the first five years of the illness in first-episode patients.

METHODS: Magnetic resonance images were acquired at baseline (T0) and after 5-year (T5) of 57 schizophrenia patients. Correlations were calculated in patients between brain volume (change), DUI and outcome variables.

RESULTS: We found no significant correlation between DUI and brain volume (change) in schizophrenia patients. A longer DUI was significantly correlated with higher PANSS scores at T0 and T5, and with higher scores on the Camberwell Assessment of Need scale at T5. Baseline volume of the cerebrum and lateral ventricles, and cerebellum volume (change) were associated with PANSS scores at T0 and T5.

CONCLUSION: Although clinical outcome is associated with both brain volume (change) and DUI, we found no evidence for a relationship between DUI and brain volume (change). DUI and baseline brain volume or 5-year brain volume (change) seem to explain different parts of the variation in clinical outcome.

Original language	English
Pages (from-to)	84-90
Number of pages	7
Journal	Schizophrenia Research
Volume	132
Issue number	1
DOIs	https://doi.org/10.1016/j.schres.2011.07.018
Publication status	Published - Oct 2011

Keywords

Adolescent
Adult
Analysis of Variance
Brain
Brain Mapping
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Psychiatric Status Rating Scales
Schizophrenia
Statistics, Nonparametric
Young Adult
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.schres.2011.07.018

http://www.ncbi.nlm.nih.gov/pubmed/21835595

Cite this

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title = "Duration of untreated illness in schizophrenia is not associated with 5-year brain volume change",

abstract = "OBJECTIVES: Evidence for an association between duration of untreated illness (DUI) with clinical and functional outcome or brain volume (change) in schizophrenia patients is inconclusive. We aimed to investigate the relationship between DUI, outcome and brain volume at illness onset or brain volume change during the first five years of the illness in first-episode patients.METHODS: Magnetic resonance images were acquired at baseline (T0) and after 5-year (T5) of 57 schizophrenia patients. Correlations were calculated in patients between brain volume (change), DUI and outcome variables.RESULTS: We found no significant correlation between DUI and brain volume (change) in schizophrenia patients. A longer DUI was significantly correlated with higher PANSS scores at T0 and T5, and with higher scores on the Camberwell Assessment of Need scale at T5. Baseline volume of the cerebrum and lateral ventricles, and cerebellum volume (change) were associated with PANSS scores at T0 and T5.CONCLUSION: Although clinical outcome is associated with both brain volume (change) and DUI, we found no evidence for a relationship between DUI and brain volume (change). DUI and baseline brain volume or 5-year brain volume (change) seem to explain different parts of the variation in clinical outcome.",

keywords = "Adolescent, Adult, Analysis of Variance, Brain, Brain Mapping, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Psychiatric Status Rating Scales, Schizophrenia, Statistics, Nonparametric, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",

author = "G. Boonstra and W. Cahn and H.G. Schnack and {Hulshoff Pol}, H.E. and T.C. Minderhoud and R.S. Kahn and {van Haren}, N.E.M.",

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language = "English",

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AU - Boonstra, G.

AU - Cahn, W.

AU - Schnack, H.G.

AU - Hulshoff Pol, H.E.

AU - Minderhoud, T.C.

AU - Kahn, R.S.

AU - van Haren, N.E.M.

PY - 2011/10

Y1 - 2011/10

N2 - OBJECTIVES: Evidence for an association between duration of untreated illness (DUI) with clinical and functional outcome or brain volume (change) in schizophrenia patients is inconclusive. We aimed to investigate the relationship between DUI, outcome and brain volume at illness onset or brain volume change during the first five years of the illness in first-episode patients.METHODS: Magnetic resonance images were acquired at baseline (T0) and after 5-year (T5) of 57 schizophrenia patients. Correlations were calculated in patients between brain volume (change), DUI and outcome variables.RESULTS: We found no significant correlation between DUI and brain volume (change) in schizophrenia patients. A longer DUI was significantly correlated with higher PANSS scores at T0 and T5, and with higher scores on the Camberwell Assessment of Need scale at T5. Baseline volume of the cerebrum and lateral ventricles, and cerebellum volume (change) were associated with PANSS scores at T0 and T5.CONCLUSION: Although clinical outcome is associated with both brain volume (change) and DUI, we found no evidence for a relationship between DUI and brain volume (change). DUI and baseline brain volume or 5-year brain volume (change) seem to explain different parts of the variation in clinical outcome.

AB - OBJECTIVES: Evidence for an association between duration of untreated illness (DUI) with clinical and functional outcome or brain volume (change) in schizophrenia patients is inconclusive. We aimed to investigate the relationship between DUI, outcome and brain volume at illness onset or brain volume change during the first five years of the illness in first-episode patients.METHODS: Magnetic resonance images were acquired at baseline (T0) and after 5-year (T5) of 57 schizophrenia patients. Correlations were calculated in patients between brain volume (change), DUI and outcome variables.RESULTS: We found no significant correlation between DUI and brain volume (change) in schizophrenia patients. A longer DUI was significantly correlated with higher PANSS scores at T0 and T5, and with higher scores on the Camberwell Assessment of Need scale at T5. Baseline volume of the cerebrum and lateral ventricles, and cerebellum volume (change) were associated with PANSS scores at T0 and T5.CONCLUSION: Although clinical outcome is associated with both brain volume (change) and DUI, we found no evidence for a relationship between DUI and brain volume (change). DUI and baseline brain volume or 5-year brain volume (change) seem to explain different parts of the variation in clinical outcome.

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Duration of untreated illness in schizophrenia is not associated with 5-year brain volume change

Abstract

Keywords

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