TY - JOUR
T1 - Drive-the-doctor paradigm in acute ischaemic stroke for improving regional stroke care networks
T2 - a cost-effectiveness analysis
AU - Nguyen, Chi Phuong
AU - Uyttenboogaart, Maarten
AU - Maas, Willemijn J.
AU - Buskens, Erik
AU - Lahr, Maarten M.H.
AU - Van Der Zee, Durk Jouke
AU - Dippel, Diederik
AU - Majoie, Charles
AU - Beusekom, Heleen van
AU - Cate, Hugo ten
AU - Dammers, Ruben
AU - Dijkhuizen, Rick
AU - Kappelle, Jaap
AU - Klijn, Karin
AU - Koudstaal, Peter
AU - Lingsma, Hester
AU - Lugt, Aad van der
AU - Maat, Moniek de
AU - Nederkoorn, Paul
AU - Oostenbrugge, Robert van
AU - Roos, Yvo
AU - Vivian, Denis
AU - Zwam, Wim van
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2025.
PY - 2025/3/29
Y1 - 2025/3/29
N2 - Background and objective In a drive-the-doctor (DD) paradigm, an interventionalist travels from a comprehensive stroke centre (CSC) to primary stroke centres (PSCs) to perform endovascular thrombectomy (EVT) for acute ischaemic stroke due to large vessel occlusion (LVO). The DD paradigm may reduce time delays from onset to recanalisation. This study aimed to analyse the cost-effectiveness of the DD paradigm versus a drip-and-ship (DS) paradigm, where LVO patients are transferred from PSCs to a CSC for EVT in the northern Netherlands. Design Economic evaluation was performed using a simulation model combined with a decision tree and a Markov model. Setting Stroke centres in the northern Netherlands. Participants A hypothetical cohort of 100 000 LVO patients with an average age of 70 years. Interventions Two strategies were tested, including the DD paradigm with one upgraded PSC and the DD paradigm with two upgraded PSCs. Main outcome measures Total costs and quality-adjusted life years (QALYs) were measured over a 15-year time horizon from a Dutch healthcare provider perspective. An incremental cost-effectiveness ratio (ICER) of €50 000 was used as a willingness-to-pay threshold. One-way sensitivity, probabilistic sensitivity and scenario analyses (interventionalist transportation by car, ambulance and helicopter) were conducted to examine parameter uncertainty. Results The DD paradigm using car as a transport modality and two PSCs was the optimal strategy, resulting in the lowest ICER. This strategy provided an additional 0.13 QALYs at incremental costs of €2367, yielding an ICER of €18 306 compared with current practice. The DD paradigm with two PSCs reduced ICERs compared with the scenario with one PSC when varying transportation modalities (car, ambulance and helicopter). Probabilistic sensitivity analyses showed that the DD paradigm with two PSCs using car was preferred in 72% of 10 000 Monte Carlo simulations. Conclusions The DD paradigm appeared cost-effective for LVO patients and may be considered a promising evolution for a regional stroke network.
AB - Background and objective In a drive-the-doctor (DD) paradigm, an interventionalist travels from a comprehensive stroke centre (CSC) to primary stroke centres (PSCs) to perform endovascular thrombectomy (EVT) for acute ischaemic stroke due to large vessel occlusion (LVO). The DD paradigm may reduce time delays from onset to recanalisation. This study aimed to analyse the cost-effectiveness of the DD paradigm versus a drip-and-ship (DS) paradigm, where LVO patients are transferred from PSCs to a CSC for EVT in the northern Netherlands. Design Economic evaluation was performed using a simulation model combined with a decision tree and a Markov model. Setting Stroke centres in the northern Netherlands. Participants A hypothetical cohort of 100 000 LVO patients with an average age of 70 years. Interventions Two strategies were tested, including the DD paradigm with one upgraded PSC and the DD paradigm with two upgraded PSCs. Main outcome measures Total costs and quality-adjusted life years (QALYs) were measured over a 15-year time horizon from a Dutch healthcare provider perspective. An incremental cost-effectiveness ratio (ICER) of €50 000 was used as a willingness-to-pay threshold. One-way sensitivity, probabilistic sensitivity and scenario analyses (interventionalist transportation by car, ambulance and helicopter) were conducted to examine parameter uncertainty. Results The DD paradigm using car as a transport modality and two PSCs was the optimal strategy, resulting in the lowest ICER. This strategy provided an additional 0.13 QALYs at incremental costs of €2367, yielding an ICER of €18 306 compared with current practice. The DD paradigm with two PSCs reduced ICERs compared with the scenario with one PSC when varying transportation modalities (car, ambulance and helicopter). Probabilistic sensitivity analyses showed that the DD paradigm with two PSCs using car was preferred in 72% of 10 000 Monte Carlo simulations. Conclusions The DD paradigm appeared cost-effective for LVO patients and may be considered a promising evolution for a regional stroke network.
KW - HEALTH ECONOMICS
KW - Organisation of health services
KW - Stroke
UR - https://www.scopus.com/pages/publications/105002541570
U2 - 10.1136/bmjopen-2024-091413
DO - 10.1136/bmjopen-2024-091413
M3 - Article
C2 - 40157729
AN - SCOPUS:105002541570
SN - 2044-6055
VL - 15
JO - BMJ Open
JF - BMJ Open
IS - 3
M1 - e091413
ER -