TY - JOUR
T1 - Drink to prevent
T2 - Review on the cardioprotective mechanisms of alcohol and red wine polyphenols
AU - De Lange, Dylan W.
AU - Van De Wiel, Albert
PY - 2004/5
Y1 - 2004/5
N2 - Moderate alcohol consumption has convincingly been associated with decreased cardiovascular mortality in epidemiological studies and metaanalyses. This decreased mortality has been attributed to changes in lipid profiles, decreased coagulation, increased fibrinolysis, inhibition of platelets, increased nitric oxide, and antioxidant capacities of alcoholic beverages. Most of these laboratory and animal studies, as well as small intervention trials in human volunteers, have revealed many interesting mechanisms that contribute to the cardioprotective effects of alcohol, red wine, or red wine polyphenolic compounds. An update on putative mechanisms is presented in this review.
AB - Moderate alcohol consumption has convincingly been associated with decreased cardiovascular mortality in epidemiological studies and metaanalyses. This decreased mortality has been attributed to changes in lipid profiles, decreased coagulation, increased fibrinolysis, inhibition of platelets, increased nitric oxide, and antioxidant capacities of alcoholic beverages. Most of these laboratory and animal studies, as well as small intervention trials in human volunteers, have revealed many interesting mechanisms that contribute to the cardioprotective effects of alcohol, red wine, or red wine polyphenolic compounds. An update on putative mechanisms is presented in this review.
KW - Alcohol
KW - Cardiovascular diseases
KW - Polyphenols
KW - Red wine
UR - http://www.scopus.com/inward/record.url?scp=7244260419&partnerID=8YFLogxK
U2 - 10.1055/s-2004-835376
DO - 10.1055/s-2004-835376
M3 - Review article
C2 - 15478039
AN - SCOPUS:7244260419
SN - 1528-9648
VL - 4
SP - 173
EP - 186
JO - Seminars in Vascular Medicine
JF - Seminars in Vascular Medicine
IS - 2
ER -