Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

Marijn Lijffijt; J Leon Kenemans; Annemiek ter Wal; Elise H Quik; C Kemner; Herman Westenberg; Marinus N Verbaten; Herman van Engeland

doi:10.1016/j.eurpsy.2005.04.003

Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

Marijn Lijffijt, J Leon Kenemans, Annemiek ter Wal, Elise H Quik, C Kemner, Herman Westenberg, Marinus N Verbaten, Herman van Engeland

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention.

SUBJECTS AND METHODS: Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.

RESULTS: Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively.

DISCUSSION AND CONCLUSION: In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.

Original language	English
Pages (from-to)	544-547
Number of pages	4
Journal	European Psychiatry
Volume	21
Issue number	8
DOIs	https://doi.org/10.1016/j.eurpsy.2005.04.003
Publication status	Published - Dec 2006

Keywords

Adolescent
Attention
Attention Deficit Disorder with Hyperactivity
Central Nervous System Stimulants
Child
Child Behavior
Dopamine
Dose-Response Relationship, Drug
Female
Humans
Inhibition (Psychology)
Internal-External Control
Male
Methylphenidate
Norepinephrine
Reaction Time
Task Performance and Analysis
Clinical Trial
Stop-signal paradigm
Blood serum

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10.1016/j.eurpsy.2005.04.003

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title = "Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder",

abstract = "PURPOSE: The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention.SUBJECTS AND METHODS: Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.RESULTS: Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively.DISCUSSION AND CONCLUSION: In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.",

keywords = "Adolescent, Attention, Attention Deficit Disorder with Hyperactivity, Central Nervous System Stimulants, Child, Child Behavior, Dopamine, Dose-Response Relationship, Drug, Female, Humans, Inhibition (Psychology), Internal-External Control, Male, Methylphenidate, Norepinephrine, Reaction Time, Task Performance and Analysis, Clinical Trial, Stop-signal paradigm, Blood serum",

author = "Marijn Lijffijt and Kenemans, {J Leon} and {ter Wal}, Annemiek and Quik, {Elise H} and C Kemner and Herman Westenberg and Verbaten, {Marinus N} and {van Engeland}, Herman",

year = "2006",

month = dec,

doi = "10.1016/j.eurpsy.2005.04.003",

language = "English",

volume = "21",

pages = "544--547",

journal = "European Psychiatry",

issn = "0924-9338",

publisher = "Cambridge University Press",

number = "8",

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TY - JOUR

T1 - Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

AU - Lijffijt, Marijn

AU - Kenemans, J Leon

AU - ter Wal, Annemiek

AU - Quik, Elise H

AU - Kemner, C

AU - Westenberg, Herman

AU - Verbaten, Marinus N

AU - van Engeland, Herman

PY - 2006/12

Y1 - 2006/12

N2 - PURPOSE: The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention.SUBJECTS AND METHODS: Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.RESULTS: Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively.DISCUSSION AND CONCLUSION: In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.

AB - PURPOSE: The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention.SUBJECTS AND METHODS: Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.RESULTS: Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively.DISCUSSION AND CONCLUSION: In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.

KW - Adolescent

KW - Attention

KW - Attention Deficit Disorder with Hyperactivity

KW - Central Nervous System Stimulants

KW - Child

KW - Child Behavior

KW - Dopamine

KW - Dose-Response Relationship, Drug

KW - Female

KW - Humans

KW - Inhibition (Psychology)

KW - Internal-External Control

KW - Male

KW - Methylphenidate

KW - Norepinephrine

KW - Reaction Time

KW - Task Performance and Analysis

KW - Clinical Trial

KW - Stop-signal paradigm

KW - Blood serum

U2 - 10.1016/j.eurpsy.2005.04.003

DO - 10.1016/j.eurpsy.2005.04.003

M3 - Article

C2 - 15994064

SN - 0924-9338

VL - 21

SP - 544

EP - 547

JO - European Psychiatry

JF - European Psychiatry

IS - 8

ER -

Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

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Keywords

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