Dose reduction with iterative reconstruction for coronary computed tomography angiography: a systematic review and meta-analysis

Annemarie M den Harder; Martin J Willemink; Quirina M B de Ruiter; Pim A de Jong; AMR Schilham; Gabriel P Krestin; Tim Leiner; Ricardo P J Budde

doi:10.1259/bjr.20150068

Dose reduction with iterative reconstruction for coronary computed tomography angiography: a systematic review and meta-analysis

Annemarie M den Harder, Martin J Willemink, Quirina M B de Ruiter, Pim A de Jong, AMR Schilham, Gabriel P Krestin, Tim Leiner, Ricardo P J Budde

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: To investigate the achievable radiation dose reduction for coronary computed tomography angiography (CCTA) with iterative reconstruction (IR) in adults and the effects on image quality.

METHODS: PubMed and EMBASE were searched and original articles concerning IR for CCTA in adults using prospective ECG-triggering were included. Primary outcome was the effective dose using filtered back projection (FBP) and IR. Secondary outcome was the effect of IR on objective and subjective image quality.

RESULTS: The search yielded 1,616 unique articles of which 10 studies (1,042 patients) were included. The pooled routine effective dose with FBP was 4.2 (95% CI 3.5 - 5.0) mSv. A dose reduction of 48% to a pooled effective dose of 2.2 (95% CI 1.3 - 3.1) mSv using IR was reported. Noise, contrast-to-noise ratio (CNR) and subjective image quality were equal or improved in all but one study while signal-to-noise ratio (SNR) was decreased in two studies with IR at reduced dose.

CONCLUSION: IR allows for CCTA acquisition with an effective dose of 2.2 mSv with preserved objective and subjective image quality.

Original language	English
Article number	20150068
Journal	British Journal of Radiology
Volume	89
Issue number	1058
Early online date	12 Nov 2015
DOIs	https://doi.org/10.1259/bjr.20150068
Publication status	Published - Dec 2015

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title = "Dose reduction with iterative reconstruction for coronary computed tomography angiography: a systematic review and meta-analysis",

abstract = "OBJECTIVES: To investigate the achievable radiation dose reduction for coronary computed tomography angiography (CCTA) with iterative reconstruction (IR) in adults and the effects on image quality.METHODS: PubMed and EMBASE were searched and original articles concerning IR for CCTA in adults using prospective ECG-triggering were included. Primary outcome was the effective dose using filtered back projection (FBP) and IR. Secondary outcome was the effect of IR on objective and subjective image quality.RESULTS: The search yielded 1,616 unique articles of which 10 studies (1,042 patients) were included. The pooled routine effective dose with FBP was 4.2 (95% CI 3.5 - 5.0) mSv. A dose reduction of 48% to a pooled effective dose of 2.2 (95% CI 1.3 - 3.1) mSv using IR was reported. Noise, contrast-to-noise ratio (CNR) and subjective image quality were equal or improved in all but one study while signal-to-noise ratio (SNR) was decreased in two studies with IR at reduced dose.CONCLUSION: IR allows for CCTA acquisition with an effective dose of 2.2 mSv with preserved objective and subjective image quality.",

author = "{den Harder}, {Annemarie M} and Willemink, {Martin J} and {de Ruiter}, {Quirina M B} and {de Jong}, {Pim A} and AMR Schilham and Krestin, {Gabriel P} and Tim Leiner and Budde, {Ricardo P J}",

year = "2015",

month = dec,

doi = "10.1259/bjr.20150068",

language = "English",

volume = "89",

journal = "British Journal of Radiology",

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publisher = "Oxford University Press",

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T1 - Dose reduction with iterative reconstruction for coronary computed tomography angiography

T2 - a systematic review and meta-analysis

AU - den Harder, Annemarie M

AU - Willemink, Martin J

AU - de Ruiter, Quirina M B

AU - de Jong, Pim A

AU - Schilham, AMR

AU - Krestin, Gabriel P

AU - Leiner, Tim

AU - Budde, Ricardo P J

PY - 2015/12

Y1 - 2015/12

N2 - OBJECTIVES: To investigate the achievable radiation dose reduction for coronary computed tomography angiography (CCTA) with iterative reconstruction (IR) in adults and the effects on image quality.METHODS: PubMed and EMBASE were searched and original articles concerning IR for CCTA in adults using prospective ECG-triggering were included. Primary outcome was the effective dose using filtered back projection (FBP) and IR. Secondary outcome was the effect of IR on objective and subjective image quality.RESULTS: The search yielded 1,616 unique articles of which 10 studies (1,042 patients) were included. The pooled routine effective dose with FBP was 4.2 (95% CI 3.5 - 5.0) mSv. A dose reduction of 48% to a pooled effective dose of 2.2 (95% CI 1.3 - 3.1) mSv using IR was reported. Noise, contrast-to-noise ratio (CNR) and subjective image quality were equal or improved in all but one study while signal-to-noise ratio (SNR) was decreased in two studies with IR at reduced dose.CONCLUSION: IR allows for CCTA acquisition with an effective dose of 2.2 mSv with preserved objective and subjective image quality.

AB - OBJECTIVES: To investigate the achievable radiation dose reduction for coronary computed tomography angiography (CCTA) with iterative reconstruction (IR) in adults and the effects on image quality.METHODS: PubMed and EMBASE were searched and original articles concerning IR for CCTA in adults using prospective ECG-triggering were included. Primary outcome was the effective dose using filtered back projection (FBP) and IR. Secondary outcome was the effect of IR on objective and subjective image quality.RESULTS: The search yielded 1,616 unique articles of which 10 studies (1,042 patients) were included. The pooled routine effective dose with FBP was 4.2 (95% CI 3.5 - 5.0) mSv. A dose reduction of 48% to a pooled effective dose of 2.2 (95% CI 1.3 - 3.1) mSv using IR was reported. Noise, contrast-to-noise ratio (CNR) and subjective image quality were equal or improved in all but one study while signal-to-noise ratio (SNR) was decreased in two studies with IR at reduced dose.CONCLUSION: IR allows for CCTA acquisition with an effective dose of 2.2 mSv with preserved objective and subjective image quality.

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DO - 10.1259/bjr.20150068

M3 - Article

C2 - 26562096

SN - 0007-1285

VL - 89

JO - British Journal of Radiology

JF - British Journal of Radiology

IS - 1058

M1 - 20150068

ER -

Dose reduction with iterative reconstruction for coronary computed tomography angiography: a systematic review and meta-analysis

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