Do functional changes occur in the bladder due to bladder outlet obstruction? - ICI-RS 2018

Ruud Bosch*, Paul Abrams, Marcio Augusto Averbeck, Enrico Finazzi Agró, Andrew Gammie, Tom Marcelissen, Eskinder Solomon

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Studies on bladder dysfunction (BD), more specifically functional-urodynamic changes in the bladder as a result of bladder outlet obstruction (BOO) have been summarized for this TT. Based on available, but limited evidence from human studies a three-stage model can be hypothesized to characterize BOO-induced bladder remodeling: hypertrophy, compensation (increased detrusor contractility during the voiding phase, often in combination with filling phase detrusor overactivity) followed by the phase of decompensation [detrusor underactivity]. The time between the start of compensation and eventual decompensation seems to be determined by age of onset, severity, and type of obstruction and clinical mitigating factors such as vascular and metabolic problems. Understanding the relative contributions of these factors may allow the development of personalized timelines and probabilities for these obstructed patients.

Original languageEnglish
Pages (from-to)S56-S65
JournalNeurourology and Urodynamics
Volume38
Issue numberS5 Supplement: ICI‐RS 2018
DOIs
Publication statusPublished - 1 Dec 2019

Keywords

  • bladder dysfunction
  • bladder outlet obstruction
  • detrusor contractility
  • overactive bladder
  • underactive bladder
  • Urinary Bladder Neck Obstruction/physiopathology
  • Urodynamics
  • Humans
  • Urinary Bladder/physiopathology

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