DNA repair mechanisms in C. elegans

Translated title of the contribution: DNA repair mechanisms in C. elegans

K. Brouwer

    Research output: ThesisDoctoral thesis 2 (Research NOT UU / Graduation UU)

    10 Downloads (Pure)


    DNA is the carrier of genetic information. DNA is constantly damaged by, for example, UV light and X-rays. Cells can utilize a large number of proteins that can repair the damages, thereby avoiding changes in the DNA sequence. Damages that are not repaired result in an increase in the number of mutations. Mutations can lead to the transformation of a normal cell to a tumor cell. This becomes clear with the observation that genes involved in DNA repair are often mutated in tumors, and that genetic forms of cancer are related to mutations in these genes. In this thesis, several DNA repair mechanisms are studied. These studies are performed in the model organism C. elegans. The nematode C. elegans has many genes in common with humans and it can easily be used in large genetic studies. The studies have resulted in the identification and characterization of new genes involved in DNA repair.
    Translated title of the contributionDNA repair mechanisms in C. elegans
    Original languageUndefined/Unknown
    QualificationDoctor of Philosophy
    Awarding Institution
    • Utrecht University
    • Cuppen, Edwin, Primary supervisor
    • Tijsterman, M., Co-supervisor, External person
    Award date6 Mar 2009
    Print ISBNs978-90-393-5017-1
    Publication statusPublished - 6 Mar 2009


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