DNA methylation differences in cortical grey and white matter in schizophrenia

Amber Berdenis Van Berlekom, Nina Notman, Marjolein A.M. Sneeboer, Gijsje J.L.J. Snijders, Lotte C. Houtepen, Danny M. Nispeling, Yujie He, Stella Dracheva, Elly M. Hol, René S. Kahn, Lot D. De Witte, Marco P. Boks*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and controls in postmortem brain cortical tissue. Materials & methods: Grey and white matter were separated from postmortem brain tissue of the superior temporal and medial frontal gyrus from SCZ (n = 10) and control (n = 11) cases. Genome-wide DNA-methylation analysis was performed using the Infinium EPIC Methylation Array (Illumina, CA, USA). Results: Four differentially methylated regions associated with SCZ status and tissue type (grey vs white matter) were identified within or near KLF9, SFXN1, SPRED2 and ALS2CL genes. Gene-expression analysis showed differential expression of KLF9 and SFXN1 in SCZ. Conclusion: Our data show distinct differences in DNA methylation between grey and white matter that are unique to SCZ, providing new leads to unravel the pathogenesis of SCZ.

Original languageEnglish
Pages (from-to)1157-1169
Number of pages13
Issue number15
Early online date29 Jul 2021
Publication statusPublished - Aug 2021


  • DNA-methylation
  • postmortem
  • schizophrenia


Dive into the research topics of 'DNA methylation differences in cortical grey and white matter in schizophrenia'. Together they form a unique fingerprint.

Cite this