Diversity of microRNAs in human and chimpanzee brain

Eugene Berezikov; Fritz Thuemmler; Linda W van Laake; Ivanela Kondova; Ronald Bontrop; Edwin Cuppen; Ronald H A Plasterk

doi:10.1038/ng1914

Diversity of microRNAs in human and chimpanzee brain

Eugene Berezikov
, Fritz Thuemmler
, Linda W van Laake
, Ivanela Kondova
, Ronald Bontrop
, Edwin Cuppen
, Ronald H A Plasterk

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.

Original language	English
Pages (from-to)	1375-7
Number of pages	3
Journal	Nature Genetics
Volume	38
Issue number	12
DOIs	https://doi.org/10.1038/ng1914
Publication status	Published - Dec 2006

Keywords

Animals
Brain
Cloning, Molecular
Conserved Sequence
Evolution, Molecular
Genetic Variation
Humans
MicroRNAs
Pan troglodytes
Species Specificity
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

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10.1038/ng1914

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title = "Diversity of microRNAs in human and chimpanzee brain",

abstract = "We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.",

keywords = "Animals, Brain, Cloning, Molecular, Conserved Sequence, Evolution, Molecular, Genetic Variation, Humans, MicroRNAs, Pan troglodytes, Species Specificity, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't",

author = "Eugene Berezikov and Fritz Thuemmler and \{van Laake\}, \{Linda W\} and Ivanela Kondova and Ronald Bontrop and Edwin Cuppen and Plasterk, \{Ronald H A\}",

year = "2006",

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AU - Berezikov, Eugene

AU - Thuemmler, Fritz

AU - van Laake, Linda W

AU - Kondova, Ivanela

AU - Bontrop, Ronald

AU - Cuppen, Edwin

AU - Plasterk, Ronald H A

PY - 2006/12

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AB - We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.

KW - Animals

KW - Brain

KW - Cloning, Molecular

KW - Conserved Sequence

KW - Evolution, Molecular

KW - Genetic Variation

KW - Humans

KW - MicroRNAs

KW - Pan troglodytes

KW - Species Specificity

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1038/ng1914

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SN - 1061-4036

VL - 38

SP - 1375

EP - 1377

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Diversity of microRNAs in human and chimpanzee brain

Abstract

Keywords

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