Disseminated Cryptococcus deuterogattii (AFLP6/VGII) infection in an Arabian horse from Dubai, United Arab Emirates

Jörg Kinne; Marina Joseph; Ulrich Wernery; Nora Nogradi; Ferry Hagen

doi:10.1016/j.riam.2017.02.007

Disseminated Cryptococcus deuterogattii (AFLP6/VGII) infection in an Arabian horse from Dubai, United Arab Emirates

Jörg Kinne
, Marina Joseph
, Ulrich Wernery
, Nora Nogradi
, Ferry Hagen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

BACKGROUND: During the past decades there has been an increase in cryptococcal infections caused by the basidiomycetous yeast species Cryptococcus gattii sensu lato, among humans and animals that live in endemic regions in Australia, Europe and the Americas. Unlike human cryptococcosis, little epidemiological data are available about C. gattii sensu lato infections in horses.

CASE REPORT: A fatal case of a disseminated C. gattii sensu lato infection in an 11-year-old Arabian gelding imported from South Africa into the United Arab Emitares is reported. Tissue samples were studied by conventional mycology procedures and the obtained cryptococcal isolate was molecularly characterized by mating-type determination, amplified fragment length polymorphism (AFLP) fingerprinting, and multi-locus sequence typing (MLST). Phylogenetic analysis was performed to investigate the geographic origin of the cryptococcal isolate. The isolate was identified as Cryptococcus deuterogattii (AFLP6/VGII), mating-type α. Phylogenetic analysis showed that it was closely related to another C. deuterogattii isolate from the Middle East.

CONCLUSIONS: A second case of a C. deuterogattii infection in the Middle East is described. It is likely that the horse acquired the infection in the Middle East, as the isolate is closely related to that of a recent human case from that region.

Original language	English
Pages (from-to)	229-232
Number of pages	4
Journal	Revista Iberoamericana de Micologia
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.riam.2017.02.007
Publication status	Published - 2017
Externally published	Yes

Keywords

Animals
Bacterial Infections/veterinary
Coinfection
Cryptococcosis/epidemiology
Cryptococcus gattii/classification
Fatal Outcome
Genotype
Horse Diseases/microbiology
Horses/microbiology
Humans
Lung/microbiology
Male
Mycological Typing Techniques
Phylogeny
United Arab Emirates/epidemiology

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10.1016/j.riam.2017.02.007

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title = "Disseminated Cryptococcus deuterogattii (AFLP6/VGII) infection in an Arabian horse from Dubai, United Arab Emirates",

abstract = "BACKGROUND: During the past decades there has been an increase in cryptococcal infections caused by the basidiomycetous yeast species Cryptococcus gattii sensu lato, among humans and animals that live in endemic regions in Australia, Europe and the Americas. Unlike human cryptococcosis, little epidemiological data are available about C. gattii sensu lato infections in horses.CASE REPORT: A fatal case of a disseminated C. gattii sensu lato infection in an 11-year-old Arabian gelding imported from South Africa into the United Arab Emitares is reported. Tissue samples were studied by conventional mycology procedures and the obtained cryptococcal isolate was molecularly characterized by mating-type determination, amplified fragment length polymorphism (AFLP) fingerprinting, and multi-locus sequence typing (MLST). Phylogenetic analysis was performed to investigate the geographic origin of the cryptococcal isolate. The isolate was identified as Cryptococcus deuterogattii (AFLP6/VGII), mating-type α. Phylogenetic analysis showed that it was closely related to another C. deuterogattii isolate from the Middle East.CONCLUSIONS: A second case of a C. deuterogattii infection in the Middle East is described. It is likely that the horse acquired the infection in the Middle East, as the isolate is closely related to that of a recent human case from that region.",

keywords = "Animals, Bacterial Infections/veterinary, Coinfection, Cryptococcosis/epidemiology, Cryptococcus gattii/classification, Fatal Outcome, Genotype, Horse Diseases/microbiology, Horses/microbiology, Humans, Lung/microbiology, Male, Mycological Typing Techniques, Phylogeny, United Arab Emirates/epidemiology",

author = "J{\"o}rg Kinne and Marina Joseph and Ulrich Wernery and Nora Nogradi and Ferry Hagen",

note = "Publisher Copyright: {\textcopyright} 2017 Asociaci{\'o}n Espa{\~n}ola de Micolog{\'i}a",

year = "2017",

doi = "10.1016/j.riam.2017.02.007",

language = "English",

volume = "34",

pages = "229--232",

journal = "Revista Iberoamericana de Micologia",

issn = "1130-1406",

publisher = "Asociacion Espanola de Micologia",

number = "4",

}

TY - JOUR

T1 - Disseminated Cryptococcus deuterogattii (AFLP6/VGII) infection in an Arabian horse from Dubai, United Arab Emirates

AU - Kinne, Jörg

AU - Joseph, Marina

AU - Wernery, Ulrich

AU - Nogradi, Nora

AU - Hagen, Ferry

PY - 2017

Y1 - 2017

N2 - BACKGROUND: During the past decades there has been an increase in cryptococcal infections caused by the basidiomycetous yeast species Cryptococcus gattii sensu lato, among humans and animals that live in endemic regions in Australia, Europe and the Americas. Unlike human cryptococcosis, little epidemiological data are available about C. gattii sensu lato infections in horses.CASE REPORT: A fatal case of a disseminated C. gattii sensu lato infection in an 11-year-old Arabian gelding imported from South Africa into the United Arab Emitares is reported. Tissue samples were studied by conventional mycology procedures and the obtained cryptococcal isolate was molecularly characterized by mating-type determination, amplified fragment length polymorphism (AFLP) fingerprinting, and multi-locus sequence typing (MLST). Phylogenetic analysis was performed to investigate the geographic origin of the cryptococcal isolate. The isolate was identified as Cryptococcus deuterogattii (AFLP6/VGII), mating-type α. Phylogenetic analysis showed that it was closely related to another C. deuterogattii isolate from the Middle East.CONCLUSIONS: A second case of a C. deuterogattii infection in the Middle East is described. It is likely that the horse acquired the infection in the Middle East, as the isolate is closely related to that of a recent human case from that region.

AB - BACKGROUND: During the past decades there has been an increase in cryptococcal infections caused by the basidiomycetous yeast species Cryptococcus gattii sensu lato, among humans and animals that live in endemic regions in Australia, Europe and the Americas. Unlike human cryptococcosis, little epidemiological data are available about C. gattii sensu lato infections in horses.CASE REPORT: A fatal case of a disseminated C. gattii sensu lato infection in an 11-year-old Arabian gelding imported from South Africa into the United Arab Emitares is reported. Tissue samples were studied by conventional mycology procedures and the obtained cryptococcal isolate was molecularly characterized by mating-type determination, amplified fragment length polymorphism (AFLP) fingerprinting, and multi-locus sequence typing (MLST). Phylogenetic analysis was performed to investigate the geographic origin of the cryptococcal isolate. The isolate was identified as Cryptococcus deuterogattii (AFLP6/VGII), mating-type α. Phylogenetic analysis showed that it was closely related to another C. deuterogattii isolate from the Middle East.CONCLUSIONS: A second case of a C. deuterogattii infection in the Middle East is described. It is likely that the horse acquired the infection in the Middle East, as the isolate is closely related to that of a recent human case from that region.

KW - Animals

KW - Bacterial Infections/veterinary

KW - Coinfection

KW - Cryptococcosis/epidemiology

KW - Cryptococcus gattii/classification

KW - Fatal Outcome

KW - Genotype

KW - Horse Diseases/microbiology

KW - Horses/microbiology

KW - Humans

KW - Lung/microbiology

KW - Male

KW - Mycological Typing Techniques

KW - Phylogeny

KW - United Arab Emirates/epidemiology

U2 - 10.1016/j.riam.2017.02.007

DO - 10.1016/j.riam.2017.02.007

M3 - Review article

C2 - 28595777

SN - 1130-1406

VL - 34

SP - 229

EP - 232

JO - Revista Iberoamericana de Micologia

JF - Revista Iberoamericana de Micologia

IS - 4

ER -

Disseminated Cryptococcus deuterogattii (AFLP6/VGII) infection in an Arabian horse from Dubai, United Arab Emirates

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Keywords

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