Dissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup

Sakshi Singh; Ashish Singh; Raja Rajkumar; Katakam Sampath Kumar; Subburaj Kadarkarai Samy; Sheikh Nizamuddin; Amita Singh; Shahnawaz Ahmed Sheikh; Vidya Peddada; Vinee Khanna; Pandichelvam Veeraiah; Aridaman Pandit; Gyaneshwer Chaubey; Lalji Singh; Kumarasamy Thangaraj

doi:10.1038/srep19157

Dissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup

Sakshi Singh, Ashish Singh, Raja Rajkumar, Katakam Sampath Kumar, Subburaj Kadarkarai Samy, Sheikh Nizamuddin, Amita Singh, Shahnawaz Ahmed Sheikh, Vidya Peddada, Vinee Khanna, Pandichelvam Veeraiah, Aridaman Pandit, Gyaneshwer Chaubey, Lalji Singh, Kumarasamy Thangaraj

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The global distribution of J2-M172 sub-haplogroups has been associated with Neolithic demic diffusion. Two branches of J2-M172, J2a-M410 and J2b-M102 make a considerable part of Y chromosome gene pool of the Indian subcontinent. We investigated the Neolithic contribution of demic dispersal from West to Indian paternal lineages, which majorly consists of haplogroups of Late Pleistocene ancestry. To accomplish this, we have analysed 3023 Y-chromosomes from different ethnic populations, of which 355 belonged to J2-M172. Comparison of our data with worldwide data, including Y-STRs of 1157 individuals and haplogroup frequencies of 6966 individuals, suggested a complex scenario that cannot be explained by a single wave of agricultural expansion from Near East to South Asia. Contrary to the widely accepted elite dominance model, we found a substantial presence of J2a-M410 and J2b-M102 haplogroups in both caste and tribal populations of India. Unlike demic spread in Eurasia, our results advocate a unique, complex and ancient arrival of J2a-M410 and J2b-M102 haplogroups into Indian subcontinent.

Original language	English
Article number	19157
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep19157
Publication status	Published - 12 Jan 2016
Externally published	Yes

Keywords

Chromosomes, Human
Chromosomes, Human, Y
Genetics, Population
Geography
Haplotypes
Humans
India
Phylogeny
Phylogeography

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10.1038/srep19157Licence: CC BY

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Singh, S., Singh, A., Rajkumar, R., Sampath Kumar, K., Kadarkarai Samy, S., Nizamuddin, S., Singh, A., Ahmed Sheikh, S., Peddada, V., Khanna, V., Veeraiah, P., Pandit, A., Chaubey, G., Singh, L., & Thangaraj, K. (2016). Dissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup. Scientific Reports, 6, Article 19157. https://doi.org/10.1038/srep19157

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title = "Dissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup",

abstract = "The global distribution of J2-M172 sub-haplogroups has been associated with Neolithic demic diffusion. Two branches of J2-M172, J2a-M410 and J2b-M102 make a considerable part of Y chromosome gene pool of the Indian subcontinent. We investigated the Neolithic contribution of demic dispersal from West to Indian paternal lineages, which majorly consists of haplogroups of Late Pleistocene ancestry. To accomplish this, we have analysed 3023 Y-chromosomes from different ethnic populations, of which 355 belonged to J2-M172. Comparison of our data with worldwide data, including Y-STRs of 1157 individuals and haplogroup frequencies of 6966 individuals, suggested a complex scenario that cannot be explained by a single wave of agricultural expansion from Near East to South Asia. Contrary to the widely accepted elite dominance model, we found a substantial presence of J2a-M410 and J2b-M102 haplogroups in both caste and tribal populations of India. Unlike demic spread in Eurasia, our results advocate a unique, complex and ancient arrival of J2a-M410 and J2b-M102 haplogroups into Indian subcontinent. ",

keywords = "Chromosomes, Human, Chromosomes, Human, Y, Genetics, Population, Geography, Haplotypes, Humans, India, Phylogeny, Phylogeography",

author = "Sakshi Singh and Ashish Singh and Raja Rajkumar and {Sampath Kumar}, Katakam and {Kadarkarai Samy}, Subburaj and Sheikh Nizamuddin and Amita Singh and {Ahmed Sheikh}, Shahnawaz and Vidya Peddada and Vinee Khanna and Pandichelvam Veeraiah and Aridaman Pandit and Gyaneshwer Chaubey and Lalji Singh and Kumarasamy Thangaraj",

year = "2016",

month = jan,

day = "12",

doi = "10.1038/srep19157",

language = "English",

volume = "6",

journal = "Scientific Reports",

issn = "2045-2322",

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Singh, S, Singh, A, Rajkumar, R, Sampath Kumar, K, Kadarkarai Samy, S, Nizamuddin, S, Singh, A, Ahmed Sheikh, S, Peddada, V, Khanna, V, Veeraiah, P, Pandit, A, Chaubey, G, Singh, L & Thangaraj, K 2016, 'Dissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup', Scientific Reports, vol. 6, 19157. https://doi.org/10.1038/srep19157

TY - JOUR

T1 - Dissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup

AU - Singh, Sakshi

AU - Singh, Ashish

AU - Rajkumar, Raja

AU - Sampath Kumar, Katakam

AU - Kadarkarai Samy, Subburaj

AU - Nizamuddin, Sheikh

AU - Singh, Amita

AU - Ahmed Sheikh, Shahnawaz

AU - Peddada, Vidya

AU - Khanna, Vinee

AU - Veeraiah, Pandichelvam

AU - Pandit, Aridaman

AU - Chaubey, Gyaneshwer

AU - Singh, Lalji

AU - Thangaraj, Kumarasamy

PY - 2016/1/12

Y1 - 2016/1/12

N2 - The global distribution of J2-M172 sub-haplogroups has been associated with Neolithic demic diffusion. Two branches of J2-M172, J2a-M410 and J2b-M102 make a considerable part of Y chromosome gene pool of the Indian subcontinent. We investigated the Neolithic contribution of demic dispersal from West to Indian paternal lineages, which majorly consists of haplogroups of Late Pleistocene ancestry. To accomplish this, we have analysed 3023 Y-chromosomes from different ethnic populations, of which 355 belonged to J2-M172. Comparison of our data with worldwide data, including Y-STRs of 1157 individuals and haplogroup frequencies of 6966 individuals, suggested a complex scenario that cannot be explained by a single wave of agricultural expansion from Near East to South Asia. Contrary to the widely accepted elite dominance model, we found a substantial presence of J2a-M410 and J2b-M102 haplogroups in both caste and tribal populations of India. Unlike demic spread in Eurasia, our results advocate a unique, complex and ancient arrival of J2a-M410 and J2b-M102 haplogroups into Indian subcontinent.

AB - The global distribution of J2-M172 sub-haplogroups has been associated with Neolithic demic diffusion. Two branches of J2-M172, J2a-M410 and J2b-M102 make a considerable part of Y chromosome gene pool of the Indian subcontinent. We investigated the Neolithic contribution of demic dispersal from West to Indian paternal lineages, which majorly consists of haplogroups of Late Pleistocene ancestry. To accomplish this, we have analysed 3023 Y-chromosomes from different ethnic populations, of which 355 belonged to J2-M172. Comparison of our data with worldwide data, including Y-STRs of 1157 individuals and haplogroup frequencies of 6966 individuals, suggested a complex scenario that cannot be explained by a single wave of agricultural expansion from Near East to South Asia. Contrary to the widely accepted elite dominance model, we found a substantial presence of J2a-M410 and J2b-M102 haplogroups in both caste and tribal populations of India. Unlike demic spread in Eurasia, our results advocate a unique, complex and ancient arrival of J2a-M410 and J2b-M102 haplogroups into Indian subcontinent.

KW - Chromosomes, Human

KW - Chromosomes, Human, Y

KW - Genetics, Population

KW - Geography

KW - Haplotypes

KW - Humans

KW - India

KW - Phylogeny

KW - Phylogeography

U2 - 10.1038/srep19157

DO - 10.1038/srep19157

M3 - Article

C2 - 26754573

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 19157

ER -

Dissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup

Abstract

Keywords

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