Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia

M.J. ten Berg; A. Huisman; P.M.L.A. van den Bemt; H. den Breeijen; A.C.G. Egberts; W.W. van Solinge

doi:10.3109/1354750X.2010.526243

Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia

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5 Citations (Scopus)

Abstract

CONTEXT: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.

OBJECTIVE: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.

MATERIALS AND METHODS: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.

RESULTS AND CONCLUSIONS: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.

Original language	English
Pages (from-to)	51-57
Number of pages	7
Journal	Biomarkers
Volume	16
Issue number	1
DOIs	https://doi.org/10.3109/1354750X.2010.526243
Publication status	Published - Feb 2011

Keywords

Biomarker
mean platelet volume
platelet distribution width

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10.3109/1354750X.2010.526243

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title = "Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia",

abstract = "CONTEXT: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.OBJECTIVE: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.MATERIALS AND METHODS: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.RESULTS AND CONCLUSIONS: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.",

keywords = "Biomarker, mean platelet volume, platelet distribution width",

author = "\{ten Berg\}, M.J. and A. Huisman and \{van den Bemt\}, P.M.L.A. and \{den Breeijen\}, H. and A.C.G. Egberts and \{van Solinge\}, W.W.",

year = "2011",

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doi = "10.3109/1354750X.2010.526243",

language = "English",

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TY - JOUR

T1 - Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia

AU - ten Berg, M.J.

AU - Huisman, A.

AU - van den Bemt, P.M.L.A.

AU - den Breeijen, H.

AU - Egberts, A.C.G.

AU - van Solinge, W.W.

PY - 2011/2

Y1 - 2011/2

N2 - CONTEXT: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.OBJECTIVE: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.MATERIALS AND METHODS: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.RESULTS AND CONCLUSIONS: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.

AB - CONTEXT: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.OBJECTIVE: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.MATERIALS AND METHODS: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.RESULTS AND CONCLUSIONS: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.

KW - Biomarker

KW - mean platelet volume

KW - platelet distribution width

UR - https://www.scopus.com/pages/publications/79251522212

U2 - 10.3109/1354750X.2010.526243

DO - 10.3109/1354750X.2010.526243

M3 - Article

C2 - 20977409

SN - 1354-750X

VL - 16

SP - 51

EP - 57

JO - Biomarkers

JF - Biomarkers

IS - 1

ER -

Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia

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Keywords

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