Discordant responses during antiretroviral therapy: role of immune activation and T cell redistribution rather than true CD4 T cell loss

Mette D Hazenberg; Sigrid A Otto; Ferdinand W N M Wit; Joep M A Lange; Dörte Hamann; Frank Miedema

doi:10.1097/00002030-200206140-00013

Discordant responses during antiretroviral therapy: role of immune activation and T cell redistribution rather than true CD4 T cell loss

Mette D Hazenberg, Sigrid A Otto, Ferdinand W N M Wit, Joep M A Lange, Dörte Hamann, Frank Miedema

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We studied T cell dynamics in four patients who initially responded well to highly active antiretroviral therapy (HAART) but subsequently experienced virological failure. Maintenance of peripheral blood CD4T cell counts was associated with low levels of immune activation. Low reactivity to rebounding virus may preserve normal T lymphocyte distribution over blood and tissues and be associated with stable peripheral blood T cell numbers in virological failures to HAART.

Original language	English
Pages (from-to)	1287-9
Number of pages	3
Journal	AIDS (London, England)
Volume	16
Issue number	9
DOIs	https://doi.org/10.1097/00002030-200206140-00013
Publication status	Published - 14 Jun 2002
Externally published	Yes

Keywords

Adult
Anti-HIV Agents/pharmacology
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes/cytology
HIV Infections/drug therapy
HIV-1/drug effects
Humans
Lymphocyte Activation/drug effects
Male
Middle Aged
RNA, Viral/analysis
Recurrence
T-Lymphocytes/cytology

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10.1097/00002030-200206140-00013

Cite this

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title = "Discordant responses during antiretroviral therapy: role of immune activation and T cell redistribution rather than true CD4 T cell loss",

abstract = "We studied T cell dynamics in four patients who initially responded well to highly active antiretroviral therapy (HAART) but subsequently experienced virological failure. Maintenance of peripheral blood CD4T cell counts was associated with low levels of immune activation. Low reactivity to rebounding virus may preserve normal T lymphocyte distribution over blood and tissues and be associated with stable peripheral blood T cell numbers in virological failures to HAART.",

keywords = "Adult, Anti-HIV Agents/pharmacology, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes/cytology, HIV Infections/drug therapy, HIV-1/drug effects, Humans, Lymphocyte Activation/drug effects, Male, Middle Aged, RNA, Viral/analysis, Recurrence, T-Lymphocytes/cytology",

author = "Hazenberg, {Mette D} and Otto, {Sigrid A} and Wit, {Ferdinand W N M} and Lange, {Joep M A} and D{\"o}rte Hamann and Frank Miedema",

year = "2002",

month = jun,

day = "14",

doi = "10.1097/00002030-200206140-00013",

language = "English",

volume = "16",

pages = "1287--9",

journal = "AIDS (London, England)",

issn = "0269-9370",

publisher = "Lippincott Williams & Wilkins",

number = "9",

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TY - JOUR

T1 - Discordant responses during antiretroviral therapy

T2 - role of immune activation and T cell redistribution rather than true CD4 T cell loss

AU - Hazenberg, Mette D

AU - Otto, Sigrid A

AU - Wit, Ferdinand W N M

AU - Lange, Joep M A

AU - Hamann, Dörte

AU - Miedema, Frank

PY - 2002/6/14

Y1 - 2002/6/14

N2 - We studied T cell dynamics in four patients who initially responded well to highly active antiretroviral therapy (HAART) but subsequently experienced virological failure. Maintenance of peripheral blood CD4T cell counts was associated with low levels of immune activation. Low reactivity to rebounding virus may preserve normal T lymphocyte distribution over blood and tissues and be associated with stable peripheral blood T cell numbers in virological failures to HAART.

AB - We studied T cell dynamics in four patients who initially responded well to highly active antiretroviral therapy (HAART) but subsequently experienced virological failure. Maintenance of peripheral blood CD4T cell counts was associated with low levels of immune activation. Low reactivity to rebounding virus may preserve normal T lymphocyte distribution over blood and tissues and be associated with stable peripheral blood T cell numbers in virological failures to HAART.

KW - Adult

KW - Anti-HIV Agents/pharmacology

KW - Antiretroviral Therapy, Highly Active

KW - CD4 Lymphocyte Count

KW - CD4-Positive T-Lymphocytes/cytology

KW - HIV Infections/drug therapy

KW - HIV-1/drug effects

KW - Humans

KW - Lymphocyte Activation/drug effects

KW - Male

KW - Middle Aged

KW - RNA, Viral/analysis

KW - Recurrence

KW - T-Lymphocytes/cytology

U2 - 10.1097/00002030-200206140-00013

DO - 10.1097/00002030-200206140-00013

M3 - Article

C2 - 12045496

SN - 0269-9370

VL - 16

SP - 1287

EP - 1289

JO - AIDS (London, England)

JF - AIDS (London, England)

IS - 9

ER -

Discordant responses during antiretroviral therapy: role of immune activation and T cell redistribution rather than true CD4 T cell loss

Abstract

Keywords

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