Discontinuation of Somatic Medication During Psychiatric Hospitalization

Background: Psychiatric hospitalization can increase the risk of discontinuation of pharmacotherapy, which may negatively influence patients’ health. Objective: To investigate the association between psychiatric hospitalization and discontinuation of somatic medication. Methods: A retrospective crossover study was performed in patients admitted to a psychiatric hospital (index date), who had got somatic medication dispensed during the 3 months prior to hospitalization. Discontinuation of somatic medication was investigated at the following time points: index date and 3, 6, and 9 months before the index date. Relative risks (RR) with 95% confidence intervals (95% CIs) of discontinuing somatic medication at the index date versus the time points before the index date were estimated using Cox regression. Results: In all, 471 hospitalized patients were included in the study; 38.9% of the patients were discontinuers on the index date. RR for discontinuation of ≥1 somatic medication was 1.88 (95% CI = 1.55-2.27) at the index date compared with the other time points and highest for patients <45 years (RR = 2.83; 95% CI = 1.92-4.18). Conclusions: Psychiatric hospitalization was associated with an almost doubled risk of discontinuation of somatic medication. Future studies should address the influence of discontinuation of care on patients’ health.