Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report

Marcus J Rijken; Rose McGready; Machteld E Boel; Marion Barends; Stephane Proux; Mupawjay Pimanpanarak; Pratap Singhasivanon; François Nosten

Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report

Marcus J Rijken, Rose McGready, Machteld E Boel, Marion Barends, Stephane Proux, Mupawjay Pimanpanarak, Pratap Singhasivanon, François Nosten

Birth Center Obstetrics - Medical

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4).

Original language	English
Pages (from-to)	543-5
Number of pages	3
Journal	American Journal of Tropical Medicine and Hygiene
Volume	78
Issue number	4
Publication status	Published - Apr 2008

Keywords

Adolescent
Adult
Animals
Antimalarials
Artemisinins
Drug Therapy, Combination
Female
Fever
Gestational Age
Gravidity
Humans
Malaria, Falciparum
Parity
Plasmodium falciparum
Plasmodium vivax
Pregnancy
Pregnancy Complications, Infectious
Quinolines
Retrospective Studies
Thailand
Journal Article
Research Support, Non-U.S. Gov't

Cite this

@article{a109d24f76fd4eadb1cb581b79cff77e,

title = "Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report",

abstract = "Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4).",

keywords = "Adolescent, Adult, Animals, Antimalarials, Artemisinins, Drug Therapy, Combination, Female, Fever, Gestational Age, Gravidity, Humans, Malaria, Falciparum, Parity, Plasmodium falciparum, Plasmodium vivax, Pregnancy, Pregnancy Complications, Infectious, Quinolines, Retrospective Studies, Thailand, Journal Article, Research Support, Non-U.S. Gov't",

author = "Rijken, {Marcus J} and Rose McGready and Boel, {Machteld E} and Marion Barends and Stephane Proux and Mupawjay Pimanpanarak and Pratap Singhasivanon and Fran{\c c}ois Nosten",

year = "2008",

month = apr,

language = "English",

volume = "78",

pages = "543--5",

journal = "American Journal of Tropical Medicine and Hygiene",

issn = "0002-9637",

publisher = "American Society of Tropical Medicine and Hygiene",

number = "4",

}

TY - JOUR

T1 - Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy

T2 - a preliminary report

AU - Rijken, Marcus J

AU - McGready, Rose

AU - Boel, Machteld E

AU - Barends, Marion

AU - Proux, Stephane

AU - Pimanpanarak, Mupawjay

AU - Singhasivanon, Pratap

AU - Nosten, François

PY - 2008/4

Y1 - 2008/4

N2 - Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4).

AB - Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4).

KW - Adolescent

KW - Adult

KW - Animals

KW - Antimalarials

KW - Artemisinins

KW - Drug Therapy, Combination

KW - Female

KW - Fever

KW - Gestational Age

KW - Gravidity

KW - Humans

KW - Malaria, Falciparum

KW - Parity

KW - Plasmodium falciparum

KW - Plasmodium vivax

KW - Pregnancy

KW - Pregnancy Complications, Infectious

KW - Quinolines

KW - Retrospective Studies

KW - Thailand

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

C2 - 18385345

SN - 0002-9637

VL - 78

SP - 543

EP - 545

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 4

ER -

Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report

Abstract

Keywords

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Cite this