Diffusion-weighted imaging in head and neck squamous cell carcinomas: a systematic review

Juliette P Driessen; Paulina M W  van Kempen; Geert J van der Heijden; Marielle E P Philippens; Frank A   Pameijer; Inge Stegeman; Chris H J   Terhaard; Luuk M  Janssen; Wilko Grolman

doi:10.1002/hed.23575

Diffusion-weighted imaging in head and neck squamous cell carcinomas: a systematic review

Juliette P Driessen, Paulina M W van Kempen, Geert J van der Heijden, Marielle E P Philippens, Frank A Pameijer, Inge Stegeman, Chris H J Terhaard, Luuk M Janssen, Wilko Grolman

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The purpose of this study was for us to review diagnostic accuracy of diffusion-weighted imaging (DWI) in primary head and neck squamous cell carcinomas (HNSCCs), detection of metastatic lymph nodes, and recurrences.

METHODS: A systematic review for studies concerning DWI was performed.

RESULTS: Ten studies fulfilled inclusion criteria. All studies showed significant higher "apparent diffusion coefficient" (ADC) in benign compared to malignant lesions. ADC thresholds for optimal discrimination varied. In detection of primary HNSCC, the accuracy of DWI ranged from 66% to 86%. In metastatic lymph nodes, the accuracy of DWI was 85% to 91% and the negative predictive value (NPV) was higher than 91%. For recurrences, the accuracy of DWI was 78% to 100% and the NPV ranged from 77% to 100%.

CONCLUSION: DWI showed consistent high accuracy and high NPV. However, available literature is sparse and varying ADC thresholds were reported. Compared to current imaging techniques, DWI showed the most potential in lymph node staging and detection of recurrences.

Original language	English
Pages (from-to)	440-8
Number of pages	9
Journal	Head and Neck
Volume	37
Issue number	3
DOIs	https://doi.org/10.1002/hed.23575
Publication status	Published - 2015

Keywords

Carcinoma, Squamous Cell
Diffusion Magnetic Resonance Imaging
Female
Head and Neck Neoplasms
Humans
Male
Total Quality Management

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10.1002/hed.23575

Cite this

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title = "Diffusion-weighted imaging in head and neck squamous cell carcinomas: a systematic review",

abstract = "BACKGROUND: The purpose of this study was for us to review diagnostic accuracy of diffusion-weighted imaging (DWI) in primary head and neck squamous cell carcinomas (HNSCCs), detection of metastatic lymph nodes, and recurrences.METHODS: A systematic review for studies concerning DWI was performed.RESULTS: Ten studies fulfilled inclusion criteria. All studies showed significant higher {"}apparent diffusion coefficient{"} (ADC) in benign compared to malignant lesions. ADC thresholds for optimal discrimination varied. In detection of primary HNSCC, the accuracy of DWI ranged from 66% to 86%. In metastatic lymph nodes, the accuracy of DWI was 85% to 91% and the negative predictive value (NPV) was higher than 91%. For recurrences, the accuracy of DWI was 78% to 100% and the NPV ranged from 77% to 100%.CONCLUSION: DWI showed consistent high accuracy and high NPV. However, available literature is sparse and varying ADC thresholds were reported. Compared to current imaging techniques, DWI showed the most potential in lymph node staging and detection of recurrences.",

keywords = "Carcinoma, Squamous Cell, Diffusion Magnetic Resonance Imaging, Female, Head and Neck Neoplasms, Humans, Male, Total Quality Management",

author = "Driessen, {Juliette P} and {van Kempen}, {Paulina M W} and {van der Heijden}, {Geert J} and Philippens, {Marielle E P} and Pameijer, {Frank A} and Inge Stegeman and Terhaard, {Chris H J} and Janssen, {Luuk M} and Wilko Grolman",

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year = "2015",

doi = "10.1002/hed.23575",

language = "English",

volume = "37",

pages = "440--8",

journal = "Head and Neck",

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T1 - Diffusion-weighted imaging in head and neck squamous cell carcinomas

T2 - a systematic review

AU - Driessen, Juliette P

AU - van Kempen, Paulina M W

AU - van der Heijden, Geert J

AU - Philippens, Marielle E P

AU - Pameijer, Frank A

AU - Stegeman, Inge

AU - Terhaard, Chris H J

AU - Janssen, Luuk M

AU - Grolman, Wilko

PY - 2015

Y1 - 2015

N2 - BACKGROUND: The purpose of this study was for us to review diagnostic accuracy of diffusion-weighted imaging (DWI) in primary head and neck squamous cell carcinomas (HNSCCs), detection of metastatic lymph nodes, and recurrences.METHODS: A systematic review for studies concerning DWI was performed.RESULTS: Ten studies fulfilled inclusion criteria. All studies showed significant higher "apparent diffusion coefficient" (ADC) in benign compared to malignant lesions. ADC thresholds for optimal discrimination varied. In detection of primary HNSCC, the accuracy of DWI ranged from 66% to 86%. In metastatic lymph nodes, the accuracy of DWI was 85% to 91% and the negative predictive value (NPV) was higher than 91%. For recurrences, the accuracy of DWI was 78% to 100% and the NPV ranged from 77% to 100%.CONCLUSION: DWI showed consistent high accuracy and high NPV. However, available literature is sparse and varying ADC thresholds were reported. Compared to current imaging techniques, DWI showed the most potential in lymph node staging and detection of recurrences.

AB - BACKGROUND: The purpose of this study was for us to review diagnostic accuracy of diffusion-weighted imaging (DWI) in primary head and neck squamous cell carcinomas (HNSCCs), detection of metastatic lymph nodes, and recurrences.METHODS: A systematic review for studies concerning DWI was performed.RESULTS: Ten studies fulfilled inclusion criteria. All studies showed significant higher "apparent diffusion coefficient" (ADC) in benign compared to malignant lesions. ADC thresholds for optimal discrimination varied. In detection of primary HNSCC, the accuracy of DWI ranged from 66% to 86%. In metastatic lymph nodes, the accuracy of DWI was 85% to 91% and the negative predictive value (NPV) was higher than 91%. For recurrences, the accuracy of DWI was 78% to 100% and the NPV ranged from 77% to 100%.CONCLUSION: DWI showed consistent high accuracy and high NPV. However, available literature is sparse and varying ADC thresholds were reported. Compared to current imaging techniques, DWI showed the most potential in lymph node staging and detection of recurrences.

KW - Carcinoma, Squamous Cell

KW - Diffusion Magnetic Resonance Imaging

KW - Female

KW - Head and Neck Neoplasms

KW - Humans

KW - Male

KW - Total Quality Management

U2 - 10.1002/hed.23575

DO - 10.1002/hed.23575

M3 - Article

C2 - 24347513

SN - 1043-3074

VL - 37

SP - 440

EP - 448

JO - Head and Neck

JF - Head and Neck

IS - 3

ER -

Diffusion-weighted imaging in head and neck squamous cell carcinomas: a systematic review

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Keywords

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