Diffusion tensor MRI of the healthy brachial plexus

Jos Oudeman; Camiel Verhamme; Maurits P. Engbersen; Mattan W.A. Caan; Mario Maas; Martijn Froeling; Aart J. Nederveen; Gustav J. Strijkers

doi:10.1371/journal.pone.0196975

Diffusion tensor MRI of the healthy brachial plexus

Jos Oudeman, Camiel Verhamme, Maurits P. Engbersen, Mattan W.A. Caan, Mario Maas, Martijn Froeling, Aart J. Nederveen, Gustav J. Strijkers

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: Diffusion Tensor MRI (DT-MRI) is a promising tool for the evaluation of brachial plexus pathology. Therefore, we introduce and evaluate a fast DT-MRI protocol (8min33s scanning with 5-10 min postprocessing time) for the brachial plexus.

MATERIALS AND METHODS: Thirty healthy volunteers within three age-groups (18-35, 36-55, and > 56) received DT-MRI of the brachial-plexus twice. Means of fractional-anisotropy (FA), mean-diffusivity (MD), axial-diffusivity (AD), and radial-diffusivity (RD) for the individual roots and trunks were evaluated. A stepwise forward approach was applied to test for correlations with age, sex, body-mass-index (BMI), bodysurface, height, and bodyweight. Within-subject, intra-rater, and inter-rater repeatability were assessed using Bland-Altman analysis, coefficient of variation (CV), intraclass-correlation (ICC), and minimal detectable difference (MDD).

RESULTS: No differences between sides and root levels were found. MD, AD, and RD correlated (P < 0.05) with bodyweight. Within-subject quantification proved repeatable with CVs for FA, MD, AD, and RD of 16%, 12%, 11%, and 14%, respectively.

DISCUSSION: The DT-MRI protocol was fast and repeatable. Found correlations should be considered in future studies of brachial plexus pathology.

Original language	English
Article number	e0196975
Pages (from-to)	1-15
Journal	PLoS ONE
Volume	13
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0196975
Publication status	Published - 9 May 2018

Keywords

Tractography
Nerve fibers
Magnetic resonance imaging
Anisotropy
Nerves
Fats
Echo planar imaging
Linear regression analysis
Echo-Planar Imaging/methods
Humans
Middle Aged
Nerve Fibers/physiology
Linear Models
Male
Young Adult
Adolescent
Adult
Female
Aged
Diffusion Magnetic Resonance Imaging/methods
Fats/metabolism
Brachial Plexus/diagnostic imaging
Diffusion Tensor Imaging/methods

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@article{c118a4b2c80043b491fa4f4e3ff2956c,

title = "Diffusion tensor MRI of the healthy brachial plexus",

abstract = "INTRODUCTION: Diffusion Tensor MRI (DT-MRI) is a promising tool for the evaluation of brachial plexus pathology. Therefore, we introduce and evaluate a fast DT-MRI protocol (8min33s scanning with 5-10 min postprocessing time) for the brachial plexus.MATERIALS AND METHODS: Thirty healthy volunteers within three age-groups (18-35, 36-55, and > 56) received DT-MRI of the brachial-plexus twice. Means of fractional-anisotropy (FA), mean-diffusivity (MD), axial-diffusivity (AD), and radial-diffusivity (RD) for the individual roots and trunks were evaluated. A stepwise forward approach was applied to test for correlations with age, sex, body-mass-index (BMI), bodysurface, height, and bodyweight. Within-subject, intra-rater, and inter-rater repeatability were assessed using Bland-Altman analysis, coefficient of variation (CV), intraclass-correlation (ICC), and minimal detectable difference (MDD).RESULTS: No differences between sides and root levels were found. MD, AD, and RD correlated (P < 0.05) with bodyweight. Within-subject quantification proved repeatable with CVs for FA, MD, AD, and RD of 16%, 12%, 11%, and 14%, respectively.DISCUSSION: The DT-MRI protocol was fast and repeatable. Found correlations should be considered in future studies of brachial plexus pathology.",

keywords = "Tractography, Nerve fibers, Magnetic resonance imaging, Anisotropy, Nerves, Fats, Echo planar imaging, Linear regression analysis, Echo-Planar Imaging/methods, Humans, Middle Aged, Nerve Fibers/physiology, Linear Models, Male, Young Adult, Adolescent, Adult, Female, Aged, Diffusion Magnetic Resonance Imaging/methods, Fats/metabolism, Brachial Plexus/diagnostic imaging, Diffusion Tensor Imaging/methods",

author = "Jos Oudeman and Camiel Verhamme and Engbersen, {Maurits P.} and Caan, {Mattan W.A.} and Mario Maas and Martijn Froeling and Nederveen, {Aart J.} and Strijkers, {Gustav J.}",

note = "Funding Information: This work was supported by grant 1203-055 from the Nuts-Ohra Foundation (Amsterdam, The Netherlands). This work was also supported by the European Union COST Action BM1304, {"}Applications of MR imaging and spectroscopy techniques in neuromuscular disease: collaboration on outcome measures and pattern recognition for diagnostics and therapy development.” The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018 Oudeman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2018",

month = may,

day = "9",

doi = "10.1371/journal.pone.0196975",

language = "English",

volume = "13",

pages = "1--15",

journal = "PLoS ONE",

issn = "1932-6203",

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TY - JOUR

T1 - Diffusion tensor MRI of the healthy brachial plexus

AU - Oudeman, Jos

AU - Verhamme, Camiel

AU - Engbersen, Maurits P.

AU - Caan, Mattan W.A.

AU - Maas, Mario

AU - Froeling, Martijn

AU - Nederveen, Aart J.

AU - Strijkers, Gustav J.

N1 - Funding Information: This work was supported by grant 1203-055 from the Nuts-Ohra Foundation (Amsterdam, The Netherlands). This work was also supported by the European Union COST Action BM1304, "Applications of MR imaging and spectroscopy techniques in neuromuscular disease: collaboration on outcome measures and pattern recognition for diagnostics and therapy development.” The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2018 Oudeman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2018/5/9

Y1 - 2018/5/9

N2 - INTRODUCTION: Diffusion Tensor MRI (DT-MRI) is a promising tool for the evaluation of brachial plexus pathology. Therefore, we introduce and evaluate a fast DT-MRI protocol (8min33s scanning with 5-10 min postprocessing time) for the brachial plexus.MATERIALS AND METHODS: Thirty healthy volunteers within three age-groups (18-35, 36-55, and > 56) received DT-MRI of the brachial-plexus twice. Means of fractional-anisotropy (FA), mean-diffusivity (MD), axial-diffusivity (AD), and radial-diffusivity (RD) for the individual roots and trunks were evaluated. A stepwise forward approach was applied to test for correlations with age, sex, body-mass-index (BMI), bodysurface, height, and bodyweight. Within-subject, intra-rater, and inter-rater repeatability were assessed using Bland-Altman analysis, coefficient of variation (CV), intraclass-correlation (ICC), and minimal detectable difference (MDD).RESULTS: No differences between sides and root levels were found. MD, AD, and RD correlated (P < 0.05) with bodyweight. Within-subject quantification proved repeatable with CVs for FA, MD, AD, and RD of 16%, 12%, 11%, and 14%, respectively.DISCUSSION: The DT-MRI protocol was fast and repeatable. Found correlations should be considered in future studies of brachial plexus pathology.

AB - INTRODUCTION: Diffusion Tensor MRI (DT-MRI) is a promising tool for the evaluation of brachial plexus pathology. Therefore, we introduce and evaluate a fast DT-MRI protocol (8min33s scanning with 5-10 min postprocessing time) for the brachial plexus.MATERIALS AND METHODS: Thirty healthy volunteers within three age-groups (18-35, 36-55, and > 56) received DT-MRI of the brachial-plexus twice. Means of fractional-anisotropy (FA), mean-diffusivity (MD), axial-diffusivity (AD), and radial-diffusivity (RD) for the individual roots and trunks were evaluated. A stepwise forward approach was applied to test for correlations with age, sex, body-mass-index (BMI), bodysurface, height, and bodyweight. Within-subject, intra-rater, and inter-rater repeatability were assessed using Bland-Altman analysis, coefficient of variation (CV), intraclass-correlation (ICC), and minimal detectable difference (MDD).RESULTS: No differences between sides and root levels were found. MD, AD, and RD correlated (P < 0.05) with bodyweight. Within-subject quantification proved repeatable with CVs for FA, MD, AD, and RD of 16%, 12%, 11%, and 14%, respectively.DISCUSSION: The DT-MRI protocol was fast and repeatable. Found correlations should be considered in future studies of brachial plexus pathology.

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KW - Nerve fibers

KW - Magnetic resonance imaging

KW - Anisotropy

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KW - Fats

KW - Echo planar imaging

KW - Linear regression analysis

KW - Echo-Planar Imaging/methods

KW - Humans

KW - Middle Aged

KW - Nerve Fibers/physiology

KW - Linear Models

KW - Male

KW - Young Adult

KW - Adolescent

KW - Adult

KW - Female

KW - Aged

KW - Diffusion Magnetic Resonance Imaging/methods

KW - Fats/metabolism

KW - Brachial Plexus/diagnostic imaging

KW - Diffusion Tensor Imaging/methods

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U2 - 10.1371/journal.pone.0196975

DO - 10.1371/journal.pone.0196975

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SN - 1932-6203

VL - 13

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EP - 15

JO - PLoS ONE

JF - PLoS ONE

IS - 5

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ER -

Diffusion tensor MRI of the healthy brachial plexus

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