Diffusion tensor imaging

Derek K. Jones; Alexander Leemans

doi:10.1007/978-1-61737-992-5_6

Diffusion tensor imaging

Derek K. Jones^*
, Alexander Leemans

^*Corresponding author for this work

Image Sciences Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

138 Citations (Scopus)

Abstract

Diffusion tensor MRI (DT-MRI) is the only non-invasive method for characterising the microstructural organization of tissue in vivo. Generating parametric maps that help to visualise different aspects of the tissue microstructure (mean diffusivity, tissue anisotropy and dominant fibre orientation) involves a number of steps from deciding on the optimal acquisition parameters on the scanner, collecting the data, pre-processing the data and fitting the model to generating final parametric maps for entry into statistical data analysis. Here, we describe an entire protocol that we have used on over 400 subjects with great success in our laboratory. In the 'Notes' section, we justify our choice of the various parameters/choices along the way so that the reader may adapt/modify the protocol to their own time/hardware constraints.

Original language	English
Title of host publication	Magnetic Resonance Neuroimaging
Subtitle of host publication	Methods and Protocols
Editors	Michel Modo, Jelte Bulte
Pages	127-144
Number of pages	18
DOIs	https://doi.org/10.1007/978-1-61737-992-5_6
Publication status	Published - 1 Dec 2010

Publication series

Name	Methods in Molecular Biology
Volume	711
ISSN (Print)	1064-3745

Keywords

data quality
Diffusion tensor
MRI
optimal
pulse sequence
sampling schemes

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10.1007/978-1-61737-992-5_6

Cite this

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KW - MRI

KW - optimal

KW - pulse sequence

KW - sampling schemes

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Diffusion tensor imaging

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