Diffusion MRI Data Processing and Analysis: A Practical Guide with ExploreDTI

Michael Connaughton*, Alexander Leemans, Erik O’Hanlon, Jane McGrath

*Corresponding author for this work

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Abstract

This chapter introduces neuroimaging researchers to the concepts and techniques of diffusion magnetic resonance imaging data processing. Using the freely available ExploreDTI software, we provide a step-by-step guide for processing multi-shell High Angular Resolution Diffusion Imaging data and generating tractography based on constrained deconvolution. Brief explanations of the rationale behind each processing step are provided to aid the researcher in understanding the concepts and principles involved. Potential processing pitfalls will be discussed, and tips for troubleshooting common issues will be provided. An additional step-by-step guide for processing DTI data using the open-access AOMIC data set is also provided, demonstrating command-line that can also be applied to process other large neuroimaging datasets.

Original languageEnglish
Title of host publicationMethods for Analyzing Large Neuroimaging Datasets
EditorsR. Whelan, H. Lemaître
PublisherHumana Press Inc.
Chapter10
Pages197-228
Number of pages32
ISBN (Electronic)978-1-0716-4260-3
ISBN (Print)978-1-0716-4259-7
DOIs
Publication statusPublished - 2025

Publication series

NameNeuromethods
Volume218
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • Diffusion
  • DTI
  • HARDI
  • Multi-shell
  • Tractography

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