Differential effects of bleeds on the development of arthropathy - basic and applied issues

L F D van Vulpen; S C Mastbergen; F P J G Lafeber; R E G Schutgens

doi:10.1111/hae.13236

Differential effects of bleeds on the development of arthropathy - basic and applied issues

L F D van Vulpen^*, S C Mastbergen, F P J G Lafeber, R E G Schutgens

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Haemophilia is characterized by a spontaneous bleeding tendency, affecting mainly the synovial joints. Recurrent joint bleeds induce a cascade of inflammatory as well as degenerative processes injuring synovium, cartilage and bone. These processes affect each other and may occur in parallel and/or sequentially. Clinically, the effects of joint bleeds are heterogeneous. A marked variability in joint damage is observed in patients with a similar bleeding history. Also late stage effects differ with some patients developing chronic synovitis, and others suffering from osteochondral degeneration called haemophilic arthropathy. This article reviews the current understanding of the pathogenesis of blood-induced joint damage, elaborates on potential explanations for the differential effects of a bleed, and discusses challenges for future research.

Original language	English
Pages (from-to)	521-527
Number of pages	7
Journal	Haemophilia
Volume	23
Issue number	4
DOIs	https://doi.org/10.1111/hae.13236
Publication status	Published - Jul 2017

Keywords

Arthropathy
Haemarthrosis
Haemophilia
Synovitis

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10.1111/hae.13236

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title = "Differential effects of bleeds on the development of arthropathy - basic and applied issues",

abstract = "Haemophilia is characterized by a spontaneous bleeding tendency, affecting mainly the synovial joints. Recurrent joint bleeds induce a cascade of inflammatory as well as degenerative processes injuring synovium, cartilage and bone. These processes affect each other and may occur in parallel and/or sequentially. Clinically, the effects of joint bleeds are heterogeneous. A marked variability in joint damage is observed in patients with a similar bleeding history. Also late stage effects differ with some patients developing chronic synovitis, and others suffering from osteochondral degeneration called haemophilic arthropathy. This article reviews the current understanding of the pathogenesis of blood-induced joint damage, elaborates on potential explanations for the differential effects of a bleed, and discusses challenges for future research.",

keywords = "Arthropathy, Haemarthrosis, Haemophilia, Synovitis",

author = "{van Vulpen}, {L F D} and Mastbergen, {S C} and Lafeber, {F P J G} and Schutgens, {R E G}",

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AU - van Vulpen, L F D

AU - Mastbergen, S C

AU - Lafeber, F P J G

AU - Schutgens, R E G

PY - 2017/7

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N2 - Haemophilia is characterized by a spontaneous bleeding tendency, affecting mainly the synovial joints. Recurrent joint bleeds induce a cascade of inflammatory as well as degenerative processes injuring synovium, cartilage and bone. These processes affect each other and may occur in parallel and/or sequentially. Clinically, the effects of joint bleeds are heterogeneous. A marked variability in joint damage is observed in patients with a similar bleeding history. Also late stage effects differ with some patients developing chronic synovitis, and others suffering from osteochondral degeneration called haemophilic arthropathy. This article reviews the current understanding of the pathogenesis of blood-induced joint damage, elaborates on potential explanations for the differential effects of a bleed, and discusses challenges for future research.

AB - Haemophilia is characterized by a spontaneous bleeding tendency, affecting mainly the synovial joints. Recurrent joint bleeds induce a cascade of inflammatory as well as degenerative processes injuring synovium, cartilage and bone. These processes affect each other and may occur in parallel and/or sequentially. Clinically, the effects of joint bleeds are heterogeneous. A marked variability in joint damage is observed in patients with a similar bleeding history. Also late stage effects differ with some patients developing chronic synovitis, and others suffering from osteochondral degeneration called haemophilic arthropathy. This article reviews the current understanding of the pathogenesis of blood-induced joint damage, elaborates on potential explanations for the differential effects of a bleed, and discusses challenges for future research.

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Differential effects of bleeds on the development of arthropathy - basic and applied issues

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Keywords

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