TY - JOUR
T1 - Different long-term duration of seroprotection against neisseria meningitidis in adolescents and middle-aged adults after a single meningococcal acwy conjugate vaccination in the netherlands
AU - Ohm, Milou
AU - van Rooijen, Debbie M.
AU - Marinović, Axel A.Bonačić
AU - van Ravenhorst, Mariëtte B.
AU - van der Heiden, Marieke
AU - Buisman, Anne Marie
AU - Sanders, Elisabeth A.M.
AU - Berbers, Guy A.M.
N1 - Funding Information:
This research was funded by the Dutch Ministry of Health, Welfare and Sport. We thank the children, their parents, and the adults who participated in the study as well as the participating Saltro employees for their excellent help with the venepunctures. We also thank Tom Wolfs from the UMC Utrecht and Nicoline van der Maas from the RIVM for being the independent physicians for the studies. We thank Ray Borrow, Public Health England, Manchester, UK for providing the MenW and MenY bacteria strains for the rSBA assay. We thank Teun Guichelaar for critically reviewing the manuscript.
Funding Information:
Funding: This research was funded by the Dutch Ministry of Health, Welfare and Sport.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/10/25
Y1 - 2020/10/25
N2 - Neisseria meningitidis is often asymptomatically carried in the nasopharynx but may cause invasive meningococcal disease, leading to morbidity and mortality. Meningococcal conjugate vaccinations induce functional protective antibodies against capsular antigens, but seroprotection wanes over time. We measured functional antibody titers five years after administration of a single dose of the meningococcal ACWY-polysaccharide-specific tetanus toxoid-conjugated (MenACWY-TT) vaccine in adolescents and middle-aged adults in the Netherlands, using the serum bactericidal antibody with baby rabbit complement (rSBA) assay. Protection was defined as rSBA titer ≥8. The meningococcal ACWY-specific serum IgG concentrations were measured with a multiplex immunoassay. Duration of protection was estimated by a bi-exponential decay model. Sufficient protection for MenC, MenW, and MenY was achieved in 94–96% of the adolescents five years postvaccination, but, in middle-aged adults, only in 32% for MenC, 65% for MenW and 71% for MenY. Median duration of protection for MenCWY was 4, 14, and 21 years, respectively, in middle-aged adults, while, in adolescents, it was 32, 98, and 33 years. Our findings suggest that adolescents, primed in early childhood with MenC conjugate vaccination, remain sufficiently protected after a single dose of MenACWY-TT vaccine. Middle-aged adults without priming vaccination show fast waning of antibodies, particularly MenC, for which protection is lost after four years.
AB - Neisseria meningitidis is often asymptomatically carried in the nasopharynx but may cause invasive meningococcal disease, leading to morbidity and mortality. Meningococcal conjugate vaccinations induce functional protective antibodies against capsular antigens, but seroprotection wanes over time. We measured functional antibody titers five years after administration of a single dose of the meningococcal ACWY-polysaccharide-specific tetanus toxoid-conjugated (MenACWY-TT) vaccine in adolescents and middle-aged adults in the Netherlands, using the serum bactericidal antibody with baby rabbit complement (rSBA) assay. Protection was defined as rSBA titer ≥8. The meningococcal ACWY-specific serum IgG concentrations were measured with a multiplex immunoassay. Duration of protection was estimated by a bi-exponential decay model. Sufficient protection for MenC, MenW, and MenY was achieved in 94–96% of the adolescents five years postvaccination, but, in middle-aged adults, only in 32% for MenC, 65% for MenW and 71% for MenY. Median duration of protection for MenCWY was 4, 14, and 21 years, respectively, in middle-aged adults, while, in adolescents, it was 32, 98, and 33 years. Our findings suggest that adolescents, primed in early childhood with MenC conjugate vaccination, remain sufficiently protected after a single dose of MenACWY-TT vaccine. Middle-aged adults without priming vaccination show fast waning of antibodies, particularly MenC, for which protection is lost after four years.
KW - Adolescents
KW - Long-term protection
KW - Middle-aged adults
KW - Neisseria meningitidis
KW - Quadrivalent meningococcal vaccine
KW - Serum bactericidal antibody assay
UR - http://www.scopus.com/inward/record.url?scp=85094132914&partnerID=8YFLogxK
U2 - 10.3390/vaccines8040624
DO - 10.3390/vaccines8040624
M3 - Article
AN - SCOPUS:85094132914
SN - 2076-393X
VL - 8
SP - 1
EP - 14
JO - Vaccines
JF - Vaccines
IS - 4
M1 - 624
ER -