TY - JOUR
T1 - Different cardiovascular risk factors are related to distinct white matter hyperintensity MRI phenotypes in older adults
AU - Keller, Jasmin A
AU - Kant, Ilse M J
AU - Slooter, Arjen J C
AU - van Montfort, Simone J T
AU - van Buchem, Mark A
AU - van Osch, Matthias J P
AU - Hendrikse, Jeroen
AU - de Bresser, Jeroen
N1 - Funding Information:
The research of Jeroen de Bresser was funded by an Alzheimer Nederland grant (WE.03-2019-08).
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/1
Y1 - 2022/1
N2 - The underlying mechanisms of the association between cardiovascular risk factors and a higher white matter hyperintensity (WMH) burden are unknown. We investigated the association between cardiovascular risk factors and advanced WMH markers in 155 non-demented older adults (mean age: 71 ± 5 years). The association between cardiovascular risk factors and quantitative MRI-based WMH shape and volume markers were examined using linear regression analysis. Presence of hypertension was associated with a more irregular shape of periventricular/confluent WMH (convexity (B (95 % CI)): -0.12 (-0.22--0.03); concavity index: 0.06 (0.02-0.11)), but not with total WMH volume (0.22 (-0.15-0.59)). Presence of diabetes was associated with deep WMH volume (0.89 (0.15-1.63)). Body mass index or hyperlipidemia showed no association with WMH markers. In conclusion, different cardiovascular risk factors seem to be related to a distinct pattern of WMH shape markers in non-demented older adults. These findings may suggest that different underlying cardiovascular pathological mechanisms lead to different WMH MRI phenotypes, which may be valuable for early detection of individuals at risk for stroke and dementia.
AB - The underlying mechanisms of the association between cardiovascular risk factors and a higher white matter hyperintensity (WMH) burden are unknown. We investigated the association between cardiovascular risk factors and advanced WMH markers in 155 non-demented older adults (mean age: 71 ± 5 years). The association between cardiovascular risk factors and quantitative MRI-based WMH shape and volume markers were examined using linear regression analysis. Presence of hypertension was associated with a more irregular shape of periventricular/confluent WMH (convexity (B (95 % CI)): -0.12 (-0.22--0.03); concavity index: 0.06 (0.02-0.11)), but not with total WMH volume (0.22 (-0.15-0.59)). Presence of diabetes was associated with deep WMH volume (0.89 (0.15-1.63)). Body mass index or hyperlipidemia showed no association with WMH markers. In conclusion, different cardiovascular risk factors seem to be related to a distinct pattern of WMH shape markers in non-demented older adults. These findings may suggest that different underlying cardiovascular pathological mechanisms lead to different WMH MRI phenotypes, which may be valuable for early detection of individuals at risk for stroke and dementia.
KW - Cardiovascular Diseases/diagnostic imaging
KW - Heart Disease Risk Factors
KW - Humans
KW - Leukoaraiosis
KW - Magnetic Resonance Imaging
KW - Phenotype
KW - Risk Factors
KW - White Matter/diagnostic imaging
KW - White matter hyperintensities
KW - Cerebral small vessel disease
KW - Cognitive decline
KW - Magnetic resonance imaging
KW - Cardiovascular risk factors
UR - http://www.scopus.com/inward/record.url?scp=85135285266&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2022.103131
DO - 10.1016/j.nicl.2022.103131
M3 - Article
C2 - 36002958
SN - 2213-1582
VL - 35
JO - NeuroImage. Clinical
JF - NeuroImage. Clinical
M1 - 103131
ER -